Glyoxylate protects against cyanide toxicity through metabolic modulation

Although cyanide’s biological effects are pleiotropic, its most obvious effects are as a metabolic poison. Cyanide potently inhibits cytochrome c oxidase and potentially other metabolic enzymes, thereby unleashing a cascade of metabolic perturbations that are believed to cause lethality. From system...

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Detalles Bibliográficos
Autores principales: Nielson, Jason R., Nath, Anjali K., Doane, Kim P., Shi, Xu, Lee, Jangwoen, Tippetts, Emily G., Saha, Kusumika, Morningstar, Jordan, Hicks, Kevin G., Chan, Adriano, Zhao, Yanbin, Kelly, Amy, Hendry-Hofer, Tara B., Witeof, Alyssa, Sips, Patrick Y., Mahon, Sari, Bebarta, Vikhyat S., Davisson, Vincent Jo, Boss, Gerry R., Rutter, Jared, MacRae, Calum A., Brenner, Matthew, Gerszten, Robert E., Peterson, Randall T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943054/
https://www.ncbi.nlm.nih.gov/pubmed/35322094
http://dx.doi.org/10.1038/s41598-022-08803-y

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