Cargando…

The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue

Using the Toponome Imaging System (TIS), a serial immunostainer, we studied the patterns of expression of multiple markers in alveolar macrophages (AM) from female mice lacking surfactant protein A (SP-A knockouts; KO) after “rescue” with exogenous SP-A1. We also used a 7-marker subset to compare wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phelps, David S., Chinchilli, Vernon M., Yang, Lili, Shearer, Debra, Weisz, Judith, Zhang, Xuesheng, Floros, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943067/ https://www.ncbi.nlm.nih.gov/pubmed/35322074 http://dx.doi.org/10.1038/s41598-022-08114-2

Ejemplares similares

Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice
por: Phelps, David S., et al.
Publicado: (2020)

Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1
por: Phelps, David S., et al.
Publicado: (2020)

Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection
por: Phelps, David S., et al.
Publicado: (2022)

In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement
por: Phelps, David S, et al.
Publicado: (2011)

Differential Sex-Dependent Regulation of the Alveolar Macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and Sex Differences Attenuation after 18 h of Ozone Exposure
por: Thorenoor, Nithyananda, et al.
Publicado: (2020)

Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions
por: Floros, Joanna, et al.
Publicado: (2021)

Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice
por: Depicolzuane, Lynnlee, et al.
Publicado: (2022)

Single-cell analysis reveals differential regulation of the alveolar macrophage actin cytoskeleton by surfactant proteins A1 and A2: implications of sex and aging
por: Tsotakos, Nikolaos, et al.
Publicado: (2016)

Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection
por: Mikerov, Anatoly N, et al.
Publicado: (2008)

A Pilot Proteomic Study of Vestibular Fluid From Patients With Vulvodynia
por: MacNeill, Colin, et al.
Publicado: (2022)

Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome
por: Noutsios, George T., et al.
Publicado: (2019)

Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences
por: Thorenoor, Nithyananda, et al.
Publicado: (2019)

Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival
por: Thorenoor, Nithyananda, et al.
Publicado: (2018)

Toponomics method for the automated quantification of membrane protein translocation
por: Domanova, Olga, et al.
Publicado: (2011)

Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A
por: Phelps, David S, et al.
Publicado: (2012)

The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A(0))
por: Thorenoor, Nithyananda, et al.
Publicado: (2022)

Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae
por: Thorenoor, Nithyananda, et al.
Publicado: (2020)

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved
por: Noutsios, George T., et al.
Publicado: (2017)

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences
por: Thorenoor, Nithyananda, et al.
Publicado: (2018)

Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure
por: Wang, Guirong, et al.
Publicado: (2019)

The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 Infection
por: Tekos, Fotios, et al.
Publicado: (2020)

Study of human SP-A, SP-B and SP-D loci: allele frequencies, linkage disequilibrium and heterozygosity in different races and ethnic groups
por: Liu, Wenlei, et al.
Publicado: (2003)

Sex and SP-A2 Dependent NAD(H) Redox Alterations in Mouse Alveolar Macrophages in Response to Ozone Exposure: Potential Implications for COVID-19
por: Xu, He N., et al.
Publicado: (2020)

Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice
por: Ali, Mehboob, et al.
Publicado: (2010)

Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences
por: Mikerov, Anatoly N, et al.
Publicado: (2008)

Impact of Surfactant Protein-A Variants on Survival in Aged Mice in Response to Klebsiella pneumoniae Infection and Ozone: Serendipity in Action
por: Thorenoor, Nithyananda, et al.
Publicado: (2020)

Novel, Non-Radioactive, Simple and Multiplex PCR-cRFLP Methods for Genotyping Human SP-A and SP-D Marker Alleles
por: DiAngelo, Susan, et al.
Publicado: (1999)

Impact of Ozone, Sex, and Gonadal Hormones on Bronchoalveolar Lavage Characteristics and Survival in SP-A KO Mice Infected with Klebsiella pneumoniae
por: Gandhi, Chintan K., et al.
Publicado: (2020)

Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis
por: Schubert, Walter
Publicado: (2015)

Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice
por: Higa, Kerin K., et al.
Publicado: (2015)

SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation
por: Yang, Linlin, et al.
Publicado: (2015)

LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms
por: Chanteux, Hugues, et al.
Publicado: (2007)

SP-D counteracts GM-CSF-mediated increase of granuloma formation by alveolar macrophages in lysinuric protein intolerance
por: Douda, David N, et al.
Publicado: (2009)

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens
por: Hart, Traver, et al.
Publicado: (2017)

Imaging NAD(H) Redox Alterations in Cryopreserved Alveolar Macrophages from Ozone-Exposed Mice and the Impact of Nutrient Starvation during Long Lag Times
por: Xu, He N., et al.
Publicado: (2021)

Alveolar Macrophage–mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor
por: Steele, Chad, et al.
Publicado: (2003)

Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes
por: Dalrymple, Heidi, et al.
Publicado: (2013)

Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth
por: Gschwend, Julia, et al.
Publicado: (2021)

Coronavirus disease 2019 (COVID‐19) in patients before, during, or after lung irradiation, and serum SP‐A and SP‐D levels
por: Ishibashi, Naoya, et al.
Publicado: (2022)

The alveolar macrophage.
por: Bowden, D H
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_5latu7hj2ukr48ogp70rlk36kb