In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient

This letter describes microevolution of a pre-XDR MTB strain isolated from a pulmonary TB patient over an 18-month exposure to BDQ. MDR-TB therapies with BDQ require a functional background regimen to prevent emergence of additional resistance. https://bit.ly/3D05qT9

Detalles Bibliográficos
Autores principales: Ghodousi, Arash, Hussain Rizvi, Alamdar, Khanzada, Faisal Masood, Akhtar, Nasim, Ghafoor, Abdul, Trovato, Alberto, Cirillo, Daniela Maria, Tahseen, Sabira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Agora
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943273/
https://www.ncbi.nlm.nih.gov/pubmed/34795042
http://dx.doi.org/10.1183/13993003.02102-2021
Descripción
Sumario:This letter describes microevolution of a pre-XDR MTB strain isolated from a pulmonary TB patient over an 18-month exposure to BDQ. MDR-TB therapies with BDQ require a functional background regimen to prevent emergence of additional resistance. https://bit.ly/3D05qT9

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