In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient

This letter describes microevolution of a pre-XDR MTB strain isolated from a pulmonary TB patient over an 18-month exposure to BDQ. MDR-TB therapies with BDQ require a functional background regimen to prevent emergence of additional resistance. https://bit.ly/3D05qT9

Detalles Bibliográficos
Autores principales: Ghodousi, Arash, Hussain Rizvi, Alamdar, Khanzada, Faisal Masood, Akhtar, Nasim, Ghafoor, Abdul, Trovato, Alberto, Cirillo, Daniela Maria, Tahseen, Sabira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Agora
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943273/
https://www.ncbi.nlm.nih.gov/pubmed/34795042
http://dx.doi.org/10.1183/13993003.02102-2021
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author Ghodousi, Arash
Hussain Rizvi, Alamdar
Khanzada, Faisal Masood
Akhtar, Nasim
Ghafoor, Abdul
Trovato, Alberto
Cirillo, Daniela Maria
Tahseen, Sabira
author_facet Ghodousi, Arash
Hussain Rizvi, Alamdar
Khanzada, Faisal Masood
Akhtar, Nasim
Ghafoor, Abdul
Trovato, Alberto
Cirillo, Daniela Maria
Tahseen, Sabira
author_sort Ghodousi, Arash
collection PubMed
description This letter describes microevolution of a pre-XDR MTB strain isolated from a pulmonary TB patient over an 18-month exposure to BDQ. MDR-TB therapies with BDQ require a functional background regimen to prevent emergence of additional resistance. https://bit.ly/3D05qT9
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spelling pubmed-89432732022-03-28 In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient Ghodousi, Arash Hussain Rizvi, Alamdar Khanzada, Faisal Masood Akhtar, Nasim Ghafoor, Abdul Trovato, Alberto Cirillo, Daniela Maria Tahseen, Sabira Eur Respir J Agora This letter describes microevolution of a pre-XDR MTB strain isolated from a pulmonary TB patient over an 18-month exposure to BDQ. MDR-TB therapies with BDQ require a functional background regimen to prevent emergence of additional resistance. https://bit.ly/3D05qT9 European Respiratory Society 2022-03-24 /pmc/articles/PMC8943273/ /pubmed/34795042 http://dx.doi.org/10.1183/13993003.02102-2021 Text en Copyright ©The authors 2022. https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Agora
Ghodousi, Arash
Hussain Rizvi, Alamdar
Khanzada, Faisal Masood
Akhtar, Nasim
Ghafoor, Abdul
Trovato, Alberto
Cirillo, Daniela Maria
Tahseen, Sabira
In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient
title In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient
title_full In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient
title_fullStr In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient
title_full_unstemmed In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient
title_short In vivo microevolution of Mycobacterium tuberculosis and transient emergence of atpE_Ala63Pro mutation during treatment in a pre-XDR TB patient
title_sort in vivo microevolution of mycobacterium tuberculosis and transient emergence of atpe_ala63pro mutation during treatment in a pre-xdr tb patient
topic Agora
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943273/
https://www.ncbi.nlm.nih.gov/pubmed/34795042
http://dx.doi.org/10.1183/13993003.02102-2021
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