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Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma

We present the case of a 58-year-old man who presented with dyspnea, cough, and weight loss and was ultimately diagnosed with pulmonary amyloidosis and multiple myeloma. Diagnosis was achieved with a lung biopsy which showed AL amyloid deposits involving the interstitium, vessels, and airway. He was...

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Detalles Bibliográficos
Autores principales: Kronen, Ryan, Ziehr, David R., Kane, Ashley E.D., VanderLaan, Paul A., Kholdani, Cyrus A., Hallowell, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943293/
https://www.ncbi.nlm.nih.gov/pubmed/35342704
http://dx.doi.org/10.1016/j.rmcr.2022.101626
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author Kronen, Ryan
Ziehr, David R.
Kane, Ashley E.D.
VanderLaan, Paul A.
Kholdani, Cyrus A.
Hallowell, Robert W.
author_facet Kronen, Ryan
Ziehr, David R.
Kane, Ashley E.D.
VanderLaan, Paul A.
Kholdani, Cyrus A.
Hallowell, Robert W.
author_sort Kronen, Ryan
collection PubMed
description We present the case of a 58-year-old man who presented with dyspnea, cough, and weight loss and was ultimately diagnosed with pulmonary amyloidosis and multiple myeloma. Diagnosis was achieved with a lung biopsy which showed AL amyloid deposits involving the interstitium, vessels, and airway. He was treated with cyclophosphamide, bortezomib, and dexamethasone but died prior to completing treatment. His case is unique for the amyloid deposition found in all three lung compartments with clear pathophysiologic manifestations of each compartment, and the rapid disease progression that led to respiratory failure and death.
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spelling pubmed-89432932022-03-25 Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma Kronen, Ryan Ziehr, David R. Kane, Ashley E.D. VanderLaan, Paul A. Kholdani, Cyrus A. Hallowell, Robert W. Respir Med Case Rep Case Report We present the case of a 58-year-old man who presented with dyspnea, cough, and weight loss and was ultimately diagnosed with pulmonary amyloidosis and multiple myeloma. Diagnosis was achieved with a lung biopsy which showed AL amyloid deposits involving the interstitium, vessels, and airway. He was treated with cyclophosphamide, bortezomib, and dexamethasone but died prior to completing treatment. His case is unique for the amyloid deposition found in all three lung compartments with clear pathophysiologic manifestations of each compartment, and the rapid disease progression that led to respiratory failure and death. Elsevier 2022-03-18 /pmc/articles/PMC8943293/ /pubmed/35342704 http://dx.doi.org/10.1016/j.rmcr.2022.101626 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kronen, Ryan
Ziehr, David R.
Kane, Ashley E.D.
VanderLaan, Paul A.
Kholdani, Cyrus A.
Hallowell, Robert W.
Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
title Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
title_full Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
title_fullStr Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
title_full_unstemmed Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
title_short Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
title_sort pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943293/
https://www.ncbi.nlm.nih.gov/pubmed/35342704
http://dx.doi.org/10.1016/j.rmcr.2022.101626
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