Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report

Disseminated carcinomatosis of the bone marrow (DCBM) is often accompanied by disseminated intravascular coagulation (DIC) and has a poor prognosis. DCBM develops most frequently in gastric cancer and is rarely associated with intrahepatic cholangiocarcinoma. A 41-year-old man was incidentally found...

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Autores principales: Okumura, Taiki, Mitsui, Kenta, Daikuhara, Seiichi, Tatai, Toshiharu, Itagaki, Hiroko, Miyabayashi, Hideharu, Gibo, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943367/
https://www.ncbi.nlm.nih.gov/pubmed/34483207
http://dx.doi.org/10.2169/internalmedicine.7688-21
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author Okumura, Taiki
Mitsui, Kenta
Daikuhara, Seiichi
Tatai, Toshiharu
Itagaki, Hiroko
Miyabayashi, Hideharu
Gibo, Yukio
author_facet Okumura, Taiki
Mitsui, Kenta
Daikuhara, Seiichi
Tatai, Toshiharu
Itagaki, Hiroko
Miyabayashi, Hideharu
Gibo, Yukio
author_sort Okumura, Taiki
collection PubMed
description Disseminated carcinomatosis of the bone marrow (DCBM) is often accompanied by disseminated intravascular coagulation (DIC) and has a poor prognosis. DCBM develops most frequently in gastric cancer and is rarely associated with intrahepatic cholangiocarcinoma. A 41-year-old man was incidentally found to have DIC on his regular visit for ulcerative colitis and was diagnosed with DCBM with intrahepatic cholangiocarcinoma. He received intensive care, including chemotherapy, but died suddenly from hyperkalemia, possibly due to tumor lysis syndrome (TLS). The autopsy showed the periductal infiltrating type of intrahepatic cholangiocarcinoma and tumor necrosis, possibly due to chemotherapy, indicating the effectiveness of chemotherapy for DCBM with intrahepatic cholangiocarcinoma.
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spelling pubmed-89433672022-04-14 Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report Okumura, Taiki Mitsui, Kenta Daikuhara, Seiichi Tatai, Toshiharu Itagaki, Hiroko Miyabayashi, Hideharu Gibo, Yukio Intern Med Case Report Disseminated carcinomatosis of the bone marrow (DCBM) is often accompanied by disseminated intravascular coagulation (DIC) and has a poor prognosis. DCBM develops most frequently in gastric cancer and is rarely associated with intrahepatic cholangiocarcinoma. A 41-year-old man was incidentally found to have DIC on his regular visit for ulcerative colitis and was diagnosed with DCBM with intrahepatic cholangiocarcinoma. He received intensive care, including chemotherapy, but died suddenly from hyperkalemia, possibly due to tumor lysis syndrome (TLS). The autopsy showed the periductal infiltrating type of intrahepatic cholangiocarcinoma and tumor necrosis, possibly due to chemotherapy, indicating the effectiveness of chemotherapy for DCBM with intrahepatic cholangiocarcinoma. The Japanese Society of Internal Medicine 2021-09-04 2022-03-01 /pmc/articles/PMC8943367/ /pubmed/34483207 http://dx.doi.org/10.2169/internalmedicine.7688-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Okumura, Taiki
Mitsui, Kenta
Daikuhara, Seiichi
Tatai, Toshiharu
Itagaki, Hiroko
Miyabayashi, Hideharu
Gibo, Yukio
Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report
title Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report
title_full Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report
title_fullStr Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report
title_full_unstemmed Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report
title_short Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report
title_sort disseminated carcinomatosis of bone marrow as the initial presentation of intrahepatic cholangiocarcinoma without jaundice: an autopsy case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943367/
https://www.ncbi.nlm.nih.gov/pubmed/34483207
http://dx.doi.org/10.2169/internalmedicine.7688-21
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