Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab

The use of biologic agents has enabled control of severe asthma, but there is a risk that eosinophilic granulomatosis with polyangiitis (EGPA) may be masked in some cases. We herein report a 71-year-old man who was administered dupilumab for 2 years to stabilize his asthma symptoms. A few months aft...

Descripción completa

Detalles Bibliográficos
Autores principales: Ikeda, Miki, Ohshima, Nobuharu, Kawashima, Masahiro, Shiina, Meiko, Kitani, Masashi, Suzukawa, Maho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943368/
https://www.ncbi.nlm.nih.gov/pubmed/34393172
http://dx.doi.org/10.2169/internalmedicine.7990-21
_version_ 1784673502264033280
author Ikeda, Miki
Ohshima, Nobuharu
Kawashima, Masahiro
Shiina, Meiko
Kitani, Masashi
Suzukawa, Maho
author_facet Ikeda, Miki
Ohshima, Nobuharu
Kawashima, Masahiro
Shiina, Meiko
Kitani, Masashi
Suzukawa, Maho
author_sort Ikeda, Miki
collection PubMed
description The use of biologic agents has enabled control of severe asthma, but there is a risk that eosinophilic granulomatosis with polyangiitis (EGPA) may be masked in some cases. We herein report a 71-year-old man who was administered dupilumab for 2 years to stabilize his asthma symptoms. A few months after discontinuation of dupilumab administration, an increase in the eosinophil count in peripheral blood, leg pain, and a rash appeared. Based on pathology, he was diagnosed with EGPA. EGPA in this case was considered to have become apparent due to the discontinuation of dupilumab administration.
format Online
Article
Text
id pubmed-8943368
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-89433682022-04-14 Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab Ikeda, Miki Ohshima, Nobuharu Kawashima, Masahiro Shiina, Meiko Kitani, Masashi Suzukawa, Maho Intern Med Case Report The use of biologic agents has enabled control of severe asthma, but there is a risk that eosinophilic granulomatosis with polyangiitis (EGPA) may be masked in some cases. We herein report a 71-year-old man who was administered dupilumab for 2 years to stabilize his asthma symptoms. A few months after discontinuation of dupilumab administration, an increase in the eosinophil count in peripheral blood, leg pain, and a rash appeared. Based on pathology, he was diagnosed with EGPA. EGPA in this case was considered to have become apparent due to the discontinuation of dupilumab administration. The Japanese Society of Internal Medicine 2021-08-13 2022-03-01 /pmc/articles/PMC8943368/ /pubmed/34393172 http://dx.doi.org/10.2169/internalmedicine.7990-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ikeda, Miki
Ohshima, Nobuharu
Kawashima, Masahiro
Shiina, Meiko
Kitani, Masashi
Suzukawa, Maho
Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab
title Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab
title_full Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab
title_fullStr Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab
title_full_unstemmed Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab
title_short Severe Asthma Where Eosinophilic Granulomatosis with Polyangiitis Became Apparent after the Discontinuation of Dupilumab
title_sort severe asthma where eosinophilic granulomatosis with polyangiitis became apparent after the discontinuation of dupilumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943368/
https://www.ncbi.nlm.nih.gov/pubmed/34393172
http://dx.doi.org/10.2169/internalmedicine.7990-21
work_keys_str_mv AT ikedamiki severeasthmawhereeosinophilicgranulomatosiswithpolyangiitisbecameapparentafterthediscontinuationofdupilumab
AT ohshimanobuharu severeasthmawhereeosinophilicgranulomatosiswithpolyangiitisbecameapparentafterthediscontinuationofdupilumab
AT kawashimamasahiro severeasthmawhereeosinophilicgranulomatosiswithpolyangiitisbecameapparentafterthediscontinuationofdupilumab
AT shiinameiko severeasthmawhereeosinophilicgranulomatosiswithpolyangiitisbecameapparentafterthediscontinuationofdupilumab
AT kitanimasashi severeasthmawhereeosinophilicgranulomatosiswithpolyangiitisbecameapparentafterthediscontinuationofdupilumab
AT suzukawamaho severeasthmawhereeosinophilicgranulomatosiswithpolyangiitisbecameapparentafterthediscontinuationofdupilumab

Ejemplares similares