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Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression

Pasireotide, which has a high affinity for somatostatin receptor (SSTR) 5, has attracted attention as a new treatment for refractory Cushing's disease. The patient was a 28-year-old man. He had refractory Cushing's disease and underwent multiple surgeries, radiotherapy, and medication ther...

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Autores principales: Mizuno, Tomoko, Inoshita, Naoko, Fukuhara, Noriaki, Tatsushima, Keita, Takeshita, Akira, Yamada, Shozo, Nishioka, Hiroshi, Takeuchi, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943369/
https://www.ncbi.nlm.nih.gov/pubmed/34471015
http://dx.doi.org/10.2169/internalmedicine.6314-20
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author Mizuno, Tomoko
Inoshita, Naoko
Fukuhara, Noriaki
Tatsushima, Keita
Takeshita, Akira
Yamada, Shozo
Nishioka, Hiroshi
Takeuchi, Yasuhiro
author_facet Mizuno, Tomoko
Inoshita, Naoko
Fukuhara, Noriaki
Tatsushima, Keita
Takeshita, Akira
Yamada, Shozo
Nishioka, Hiroshi
Takeuchi, Yasuhiro
author_sort Mizuno, Tomoko
collection PubMed
description Pasireotide, which has a high affinity for somatostatin receptor (SSTR) 5, has attracted attention as a new treatment for refractory Cushing's disease. The patient was a 28-year-old man. He had refractory Cushing's disease and underwent multiple surgeries, radiotherapy, and medication therapy. An examination of the adenoma by immunohistochemistry revealed a low SSTR5 expression. An USP8 mutation was not detected by reverse transcription polymerase chain reaction. Although we administered pasireotide, it was ineffective. While a further investigation is necessary, the analysis of SSTR5 expression may support the prediction of the efficiency of pasireotide for Cushing's disease. We report this case as a useful reference when considering whether or not to use pasireotide for refractory corticotroph adenomas.
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spelling pubmed-89433692022-04-14 Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression Mizuno, Tomoko Inoshita, Naoko Fukuhara, Noriaki Tatsushima, Keita Takeshita, Akira Yamada, Shozo Nishioka, Hiroshi Takeuchi, Yasuhiro Intern Med Case Report Pasireotide, which has a high affinity for somatostatin receptor (SSTR) 5, has attracted attention as a new treatment for refractory Cushing's disease. The patient was a 28-year-old man. He had refractory Cushing's disease and underwent multiple surgeries, radiotherapy, and medication therapy. An examination of the adenoma by immunohistochemistry revealed a low SSTR5 expression. An USP8 mutation was not detected by reverse transcription polymerase chain reaction. Although we administered pasireotide, it was ineffective. While a further investigation is necessary, the analysis of SSTR5 expression may support the prediction of the efficiency of pasireotide for Cushing's disease. We report this case as a useful reference when considering whether or not to use pasireotide for refractory corticotroph adenomas. The Japanese Society of Internal Medicine 2021-08-31 2022-03-01 /pmc/articles/PMC8943369/ /pubmed/34471015 http://dx.doi.org/10.2169/internalmedicine.6314-20 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mizuno, Tomoko
Inoshita, Naoko
Fukuhara, Noriaki
Tatsushima, Keita
Takeshita, Akira
Yamada, Shozo
Nishioka, Hiroshi
Takeuchi, Yasuhiro
Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression
title Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression
title_full Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression
title_fullStr Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression
title_full_unstemmed Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression
title_short Pasireotide-resistant Refractory Cushing's Disease without Somatostatin Receptor 5 Expression
title_sort pasireotide-resistant refractory cushing's disease without somatostatin receptor 5 expression
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943369/
https://www.ncbi.nlm.nih.gov/pubmed/34471015
http://dx.doi.org/10.2169/internalmedicine.6314-20
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