How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice

The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched controls. Understanding the practical aspects of choosing t...

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Autor principal: Guru Murthy, Guru Subramanian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943651/
https://www.ncbi.nlm.nih.gov/pubmed/35340664
http://dx.doi.org/10.2147/BLCTT.S219160
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author Guru Murthy, Guru Subramanian
author_facet Guru Murthy, Guru Subramanian
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description The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched controls. Understanding the practical aspects of choosing the appropriate TKI, monitoring response and side-effects are key to long term success. Currently, treatment cessation is also an option in patients achieving sustained deep molecular response. Novel agents are needed in patients with lack of response to TKI and in those with advanced disease.
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spelling pubmed-89436512022-03-25 How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice Guru Murthy, Guru Subramanian Blood Lymphat Cancer Perspectives The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched controls. Understanding the practical aspects of choosing the appropriate TKI, monitoring response and side-effects are key to long term success. Currently, treatment cessation is also an option in patients achieving sustained deep molecular response. Novel agents are needed in patients with lack of response to TKI and in those with advanced disease. Dove 2022-03-19 /pmc/articles/PMC8943651/ /pubmed/35340664 http://dx.doi.org/10.2147/BLCTT.S219160 Text en © 2022 Guru Murthy. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Perspectives
Guru Murthy, Guru Subramanian
How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice
title How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice
title_full How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice
title_fullStr How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice
title_full_unstemmed How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice
title_short How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice
title_sort how i manage patients with chronic myeloid leukemia (cml): perspectives from clinical practice
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943651/
https://www.ncbi.nlm.nih.gov/pubmed/35340664
http://dx.doi.org/10.2147/BLCTT.S219160
work_keys_str_mv AT gurumurthygurusubramanian howimanagepatientswithchronicmyeloidleukemiacmlperspectivesfromclinicalpractice

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