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How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice
The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched controls. Understanding the practical aspects of choosing t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943651/ https://www.ncbi.nlm.nih.gov/pubmed/35340664 http://dx.doi.org/10.2147/BLCTT.S219160 |
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author | Guru Murthy, Guru Subramanian |
author_facet | Guru Murthy, Guru Subramanian |
author_sort | Guru Murthy, Guru Subramanian |
collection | PubMed |
description | The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched controls. Understanding the practical aspects of choosing the appropriate TKI, monitoring response and side-effects are key to long term success. Currently, treatment cessation is also an option in patients achieving sustained deep molecular response. Novel agents are needed in patients with lack of response to TKI and in those with advanced disease. |
format | Online Article Text |
id | pubmed-8943651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-89436512022-03-25 How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice Guru Murthy, Guru Subramanian Blood Lymphat Cancer Perspectives The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched controls. Understanding the practical aspects of choosing the appropriate TKI, monitoring response and side-effects are key to long term success. Currently, treatment cessation is also an option in patients achieving sustained deep molecular response. Novel agents are needed in patients with lack of response to TKI and in those with advanced disease. Dove 2022-03-19 /pmc/articles/PMC8943651/ /pubmed/35340664 http://dx.doi.org/10.2147/BLCTT.S219160 Text en © 2022 Guru Murthy. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Perspectives Guru Murthy, Guru Subramanian How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice |
title | How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice |
title_full | How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice |
title_fullStr | How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice |
title_full_unstemmed | How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice |
title_short | How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice |
title_sort | how i manage patients with chronic myeloid leukemia (cml): perspectives from clinical practice |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943651/ https://www.ncbi.nlm.nih.gov/pubmed/35340664 http://dx.doi.org/10.2147/BLCTT.S219160 |
work_keys_str_mv | AT gurumurthygurusubramanian howimanagepatientswithchronicmyeloidleukemiacmlperspectivesfromclinicalpractice |