Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles

A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size distribution: 2–3 and ~37 nm. The main active centers of complexation with nanoparticles are the amino and hydroxyl groups of chitosan. In experim...

Descripción completa

Detalles Bibliográficos
Autores principales: Apryatina, K. V., Murach, E. I., Amarantov, S. V., Erlykina, E. I., Veselov, V. S., Smirnova, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943790/
https://www.ncbi.nlm.nih.gov/pubmed/35345603
http://dx.doi.org/10.1134/S0003683822020028
_version_ 1784673590090661888
author Apryatina, K. V.
Murach, E. I.
Amarantov, S. V.
Erlykina, E. I.
Veselov, V. S.
Smirnova, L. A.
author_facet Apryatina, K. V.
Murach, E. I.
Amarantov, S. V.
Erlykina, E. I.
Veselov, V. S.
Smirnova, L. A.
author_sort Apryatina, K. V.
collection PubMed
description A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size distribution: 2–3 and ~37 nm. The main active centers of complexation with nanoparticles are the amino and hydroxyl groups of chitosan. In experiments on culturing fibroblasts of the hTERT BJ-5ta cell line on sample films, high biocompatibility of the composition was shown. It was shown that the composition of chitosan-selenium nanoparticles has a corrective effect on the oxidative processes of the body, reducing the activity of free-radical oxidation in the blood of animals. This opens up prospects for the use of this complex in the composition of antioxidant and adaptogenic drugs.
format Online
Article
Text
id pubmed-8943790
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Pleiades Publishing
record_format MEDLINE/PubMed
spelling pubmed-89437902022-03-24 Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles Apryatina, K. V. Murach, E. I. Amarantov, S. V. Erlykina, E. I. Veselov, V. S. Smirnova, L. A. Appl Biochem Microbiol Article A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size distribution: 2–3 and ~37 nm. The main active centers of complexation with nanoparticles are the amino and hydroxyl groups of chitosan. In experiments on culturing fibroblasts of the hTERT BJ-5ta cell line on sample films, high biocompatibility of the composition was shown. It was shown that the composition of chitosan-selenium nanoparticles has a corrective effect on the oxidative processes of the body, reducing the activity of free-radical oxidation in the blood of animals. This opens up prospects for the use of this complex in the composition of antioxidant and adaptogenic drugs. Pleiades Publishing 2022-03-24 2022 /pmc/articles/PMC8943790/ /pubmed/35345603 http://dx.doi.org/10.1134/S0003683822020028 Text en © Pleiades Publishing, Inc. 2022, ISSN 0003-6838, Applied Biochemistry and Microbiology, 2022, Vol. 58, No. 2, pp. 126–131. © Pleiades Publishing, Inc., 2022.Russian Text © The Author(s), 2022, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2022, Vol. 58, No. 2, pp. 140–145. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Apryatina, K. V.
Murach, E. I.
Amarantov, S. V.
Erlykina, E. I.
Veselov, V. S.
Smirnova, L. A.
Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
title Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
title_full Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
title_fullStr Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
title_full_unstemmed Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
title_short Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
title_sort synthesis of a bioactive composition of chitosan–selenium nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943790/
https://www.ncbi.nlm.nih.gov/pubmed/35345603
http://dx.doi.org/10.1134/S0003683822020028
work_keys_str_mv AT apryatinakv synthesisofabioactivecompositionofchitosanseleniumnanoparticles
AT murachei synthesisofabioactivecompositionofchitosanseleniumnanoparticles
AT amarantovsv synthesisofabioactivecompositionofchitosanseleniumnanoparticles
AT erlykinaei synthesisofabioactivecompositionofchitosanseleniumnanoparticles
AT veselovvs synthesisofabioactivecompositionofchitosanseleniumnanoparticles
AT smirnovala synthesisofabioactivecompositionofchitosanseleniumnanoparticles

Ejemplares similares