Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification

Ruthenaelectro(ii/iv)-catalyzed intermolecular C–H acyloxylations of phenols have been developed by guidance of experimental, CV and computational insights. The use of electricity bypassed the need for stoichiometric chemical oxidants. The sustainable electrocatalysis strategy was characterized by a...

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Autores principales: Hou, Xiaoyan, Kaplaneris, Nikolaos, Yuan, Binbin, Frey, Johanna, Ohyama, Tsuyoshi, Messinis, Antonis M., Ackermann, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943857/
https://www.ncbi.nlm.nih.gov/pubmed/35432858
http://dx.doi.org/10.1039/d1sc07267f
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author Hou, Xiaoyan
Kaplaneris, Nikolaos
Yuan, Binbin
Frey, Johanna
Ohyama, Tsuyoshi
Messinis, Antonis M.
Ackermann, Lutz
author_facet Hou, Xiaoyan
Kaplaneris, Nikolaos
Yuan, Binbin
Frey, Johanna
Ohyama, Tsuyoshi
Messinis, Antonis M.
Ackermann, Lutz
author_sort Hou, Xiaoyan
collection PubMed
description Ruthenaelectro(ii/iv)-catalyzed intermolecular C–H acyloxylations of phenols have been developed by guidance of experimental, CV and computational insights. The use of electricity bypassed the need for stoichiometric chemical oxidants. The sustainable electrocatalysis strategy was characterized by ample scope, and its unique robustness enabled the late-stage C–H diversification of tyrosine-derived peptides.
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spelling pubmed-89438572022-04-14 Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification Hou, Xiaoyan Kaplaneris, Nikolaos Yuan, Binbin Frey, Johanna Ohyama, Tsuyoshi Messinis, Antonis M. Ackermann, Lutz Chem Sci Chemistry Ruthenaelectro(ii/iv)-catalyzed intermolecular C–H acyloxylations of phenols have been developed by guidance of experimental, CV and computational insights. The use of electricity bypassed the need for stoichiometric chemical oxidants. The sustainable electrocatalysis strategy was characterized by ample scope, and its unique robustness enabled the late-stage C–H diversification of tyrosine-derived peptides. The Royal Society of Chemistry 2022-02-25 /pmc/articles/PMC8943857/ /pubmed/35432858 http://dx.doi.org/10.1039/d1sc07267f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hou, Xiaoyan
Kaplaneris, Nikolaos
Yuan, Binbin
Frey, Johanna
Ohyama, Tsuyoshi
Messinis, Antonis M.
Ackermann, Lutz
Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification
title Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification
title_full Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification
title_fullStr Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification
title_full_unstemmed Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification
title_short Ruthenaelectro-catalyzed C–H acyloxylation for late-stage tyrosine and oligopeptide diversification
title_sort ruthenaelectro-catalyzed c–h acyloxylation for late-stage tyrosine and oligopeptide diversification
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943857/
https://www.ncbi.nlm.nih.gov/pubmed/35432858
http://dx.doi.org/10.1039/d1sc07267f
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