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Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients
INTRODUCTION: Studies have shown that the renin angiotensin aldosterone system (RAAS) and inflammation are related to kidney injury progression. The aim of this study was to evaluate RAAS molecules and chemokine (C-C motif) ligand 2 (CCL2) in 82 patients with chronic kidney disease (CKD). METHODS: P...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Nefrologia
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943881/ https://www.ncbi.nlm.nih.gov/pubmed/34251390 http://dx.doi.org/10.1590/2175-8239-JBN-2021-0030 |
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author | Schettini, Isabella Viana Gomes Faria, Débora Vargas Nogueira, Leilismara Sousa Otoni, Alba Silva, Ana Cristina Simões e Rios, Danyelle Romana Alves |
author_facet | Schettini, Isabella Viana Gomes Faria, Débora Vargas Nogueira, Leilismara Sousa Otoni, Alba Silva, Ana Cristina Simões e Rios, Danyelle Romana Alves |
author_sort | Schettini, Isabella Viana Gomes |
collection | PubMed |
description | INTRODUCTION: Studies have shown that the renin angiotensin aldosterone system (RAAS) and inflammation are related to kidney injury progression. The aim of this study was to evaluate RAAS molecules and chemokine (C-C motif) ligand 2 (CCL2) in 82 patients with chronic kidney disease (CKD). METHODS: Patients were divided into two groups: patients diagnosed with CKD and patients without a CKD diagnosis. Glomerular filtration rate (GFR) and albumin/creatinine ratio (ACR) were determined, as well as plasma levels of angiotensin-(1-7) [Ang-(1-7)], angiotensin-converting enzyme (ACE)1, ACE2, and plasma and urinary levels of CCL2. RESULTS: CCL2 plasma levels were significantly higher in patients with CKD compared to the control group. Patients with lower GFR had higher plasma levels of ACE2 and CCL2 and lower ratio ACE1/ACE2. Patients with higher ACR values had higher ACE1 plasma levels. CONCLUSION: Patients with CKD showed greater activity of both RAAS axes, the classic and alternative, and higher plasma levels of CCL2. Therefore, plasma levels of RAAS molecules and CCL2 seem to be promising prognostic markers and even therapeutic targets for CKD. |
format | Online Article Text |
id | pubmed-8943881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira de Nefrologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-89438812022-04-04 Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients Schettini, Isabella Viana Gomes Faria, Débora Vargas Nogueira, Leilismara Sousa Otoni, Alba Silva, Ana Cristina Simões e Rios, Danyelle Romana Alves J Bras Nefrol Original Articles INTRODUCTION: Studies have shown that the renin angiotensin aldosterone system (RAAS) and inflammation are related to kidney injury progression. The aim of this study was to evaluate RAAS molecules and chemokine (C-C motif) ligand 2 (CCL2) in 82 patients with chronic kidney disease (CKD). METHODS: Patients were divided into two groups: patients diagnosed with CKD and patients without a CKD diagnosis. Glomerular filtration rate (GFR) and albumin/creatinine ratio (ACR) were determined, as well as plasma levels of angiotensin-(1-7) [Ang-(1-7)], angiotensin-converting enzyme (ACE)1, ACE2, and plasma and urinary levels of CCL2. RESULTS: CCL2 plasma levels were significantly higher in patients with CKD compared to the control group. Patients with lower GFR had higher plasma levels of ACE2 and CCL2 and lower ratio ACE1/ACE2. Patients with higher ACR values had higher ACE1 plasma levels. CONCLUSION: Patients with CKD showed greater activity of both RAAS axes, the classic and alternative, and higher plasma levels of CCL2. Therefore, plasma levels of RAAS molecules and CCL2 seem to be promising prognostic markers and even therapeutic targets for CKD. Sociedade Brasileira de Nefrologia 2021-07-07 2022 /pmc/articles/PMC8943881/ /pubmed/34251390 http://dx.doi.org/10.1590/2175-8239-JBN-2021-0030 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Schettini, Isabella Viana Gomes Faria, Débora Vargas Nogueira, Leilismara Sousa Otoni, Alba Silva, Ana Cristina Simões e Rios, Danyelle Romana Alves Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients |
title | Renin angiotensin system molecules and chemokine (C-C motif) ligand 2
(CCL2) in chronic kidney disease patients |
title_full | Renin angiotensin system molecules and chemokine (C-C motif) ligand 2
(CCL2) in chronic kidney disease patients |
title_fullStr | Renin angiotensin system molecules and chemokine (C-C motif) ligand 2
(CCL2) in chronic kidney disease patients |
title_full_unstemmed | Renin angiotensin system molecules and chemokine (C-C motif) ligand 2
(CCL2) in chronic kidney disease patients |
title_short | Renin angiotensin system molecules and chemokine (C-C motif) ligand 2
(CCL2) in chronic kidney disease patients |
title_sort | renin angiotensin system molecules and chemokine (c-c motif) ligand 2
(ccl2) in chronic kidney disease patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943881/ https://www.ncbi.nlm.nih.gov/pubmed/34251390 http://dx.doi.org/10.1590/2175-8239-JBN-2021-0030 |
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