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Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients

INTRODUCTION: Studies have shown that the renin angiotensin aldosterone system (RAAS) and inflammation are related to kidney injury progression. The aim of this study was to evaluate RAAS molecules and chemokine (C-C motif) ligand 2 (CCL2) in 82 patients with chronic kidney disease (CKD). METHODS: P...

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Autores principales: Schettini, Isabella Viana Gomes, Faria, Débora Vargas, Nogueira, Leilismara Sousa, Otoni, Alba, Silva, Ana Cristina Simões e, Rios, Danyelle Romana Alves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Nefrologia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943881/
https://www.ncbi.nlm.nih.gov/pubmed/34251390
http://dx.doi.org/10.1590/2175-8239-JBN-2021-0030
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author Schettini, Isabella Viana Gomes
Faria, Débora Vargas
Nogueira, Leilismara Sousa
Otoni, Alba
Silva, Ana Cristina Simões e
Rios, Danyelle Romana Alves
author_facet Schettini, Isabella Viana Gomes
Faria, Débora Vargas
Nogueira, Leilismara Sousa
Otoni, Alba
Silva, Ana Cristina Simões e
Rios, Danyelle Romana Alves
author_sort Schettini, Isabella Viana Gomes
collection PubMed
description INTRODUCTION: Studies have shown that the renin angiotensin aldosterone system (RAAS) and inflammation are related to kidney injury progression. The aim of this study was to evaluate RAAS molecules and chemokine (C-C motif) ligand 2 (CCL2) in 82 patients with chronic kidney disease (CKD). METHODS: Patients were divided into two groups: patients diagnosed with CKD and patients without a CKD diagnosis. Glomerular filtration rate (GFR) and albumin/creatinine ratio (ACR) were determined, as well as plasma levels of angiotensin-(1-7) [Ang-(1-7)], angiotensin-converting enzyme (ACE)1, ACE2, and plasma and urinary levels of CCL2. RESULTS: CCL2 plasma levels were significantly higher in patients with CKD compared to the control group. Patients with lower GFR had higher plasma levels of ACE2 and CCL2 and lower ratio ACE1/ACE2. Patients with higher ACR values had higher ACE1 plasma levels. CONCLUSION: Patients with CKD showed greater activity of both RAAS axes, the classic and alternative, and higher plasma levels of CCL2. Therefore, plasma levels of RAAS molecules and CCL2 seem to be promising prognostic markers and even therapeutic targets for CKD.
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spelling pubmed-89438812022-04-04 Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients Schettini, Isabella Viana Gomes Faria, Débora Vargas Nogueira, Leilismara Sousa Otoni, Alba Silva, Ana Cristina Simões e Rios, Danyelle Romana Alves J Bras Nefrol Original Articles INTRODUCTION: Studies have shown that the renin angiotensin aldosterone system (RAAS) and inflammation are related to kidney injury progression. The aim of this study was to evaluate RAAS molecules and chemokine (C-C motif) ligand 2 (CCL2) in 82 patients with chronic kidney disease (CKD). METHODS: Patients were divided into two groups: patients diagnosed with CKD and patients without a CKD diagnosis. Glomerular filtration rate (GFR) and albumin/creatinine ratio (ACR) were determined, as well as plasma levels of angiotensin-(1-7) [Ang-(1-7)], angiotensin-converting enzyme (ACE)1, ACE2, and plasma and urinary levels of CCL2. RESULTS: CCL2 plasma levels were significantly higher in patients with CKD compared to the control group. Patients with lower GFR had higher plasma levels of ACE2 and CCL2 and lower ratio ACE1/ACE2. Patients with higher ACR values had higher ACE1 plasma levels. CONCLUSION: Patients with CKD showed greater activity of both RAAS axes, the classic and alternative, and higher plasma levels of CCL2. Therefore, plasma levels of RAAS molecules and CCL2 seem to be promising prognostic markers and even therapeutic targets for CKD. Sociedade Brasileira de Nefrologia 2021-07-07 2022 /pmc/articles/PMC8943881/ /pubmed/34251390 http://dx.doi.org/10.1590/2175-8239-JBN-2021-0030 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Schettini, Isabella Viana Gomes
Faria, Débora Vargas
Nogueira, Leilismara Sousa
Otoni, Alba
Silva, Ana Cristina Simões e
Rios, Danyelle Romana Alves
Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients
title Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients
title_full Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients
title_fullStr Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients
title_full_unstemmed Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients
title_short Renin angiotensin system molecules and chemokine (C-C motif) ligand 2 (CCL2) in chronic kidney disease patients
title_sort renin angiotensin system molecules and chemokine (c-c motif) ligand 2 (ccl2) in chronic kidney disease patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943881/
https://www.ncbi.nlm.nih.gov/pubmed/34251390
http://dx.doi.org/10.1590/2175-8239-JBN-2021-0030
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