Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and selective activity against Gram-negative pathogens, incl...

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Detalles Bibliográficos
Autores principales: Al Ayed, Karol, Ballantine, Ross D., Hoekstra, Michael, Bann, Samantha J., Wesseling, Charlotte M. J., Bakker, Alexander T., Zhong, Zheng, Li, Yong-Xin, Brüchle, Nora C., van der Stelt, Mario, Cochrane, Stephen A., Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943889/
https://www.ncbi.nlm.nih.gov/pubmed/35432860
http://dx.doi.org/10.1039/d2sc00143h

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