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Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder
BACKGROUND: Few research works have explored female sexual dysfunction (FSD) in patients with Neuromyelitis optica spectrum disorder (NMOSD) which remains an ignored disease symptom. This work aimed to describe the frequency, patterns, and predictors of FSD in a sample of newly diagnosed AQP4-ab ser...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943970/ https://www.ncbi.nlm.nih.gov/pubmed/35331161 http://dx.doi.org/10.1186/s12883-022-02648-8 |
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author | ELmazny, Alaa Salama, Sara Hussein, Mona Elsebaie, Eman Hany Magdy, Rehab |
author_facet | ELmazny, Alaa Salama, Sara Hussein, Mona Elsebaie, Eman Hany Magdy, Rehab |
author_sort | ELmazny, Alaa |
collection | PubMed |
description | BACKGROUND: Few research works have explored female sexual dysfunction (FSD) in patients with Neuromyelitis optica spectrum disorder (NMOSD) which remains an ignored disease symptom. This work aimed to describe the frequency, patterns, and predictors of FSD in a sample of newly diagnosed AQP4-ab seropositive NMOSD patients. METHODS: This case-control study was conducted on 28 seropositive NMOSD patients and 31 age matched healthy controls. All included patients were asked to privately fill and hand back the following questionnaires: female sexual function index questionnaire (FSFI), Beck depression inventory II (BDI) and fatigue severity scale (FSS). Also, Modified Modified Ashworth scale (MMAS) and Expanded disability status scale (EDSS) were applied to all included patients. RESULTS: NMOSD patients had significantly lower total FSFI scores and significantly higher BDI and FSS scores than controls (P < 0.001). FSS scores were negatively correlated with total scores of FSFI as well as desire, lubrication, orgasm, and satisfaction scores. BDI scores was negatively correlated with desire and orgasm scores. The uncorrected visual FS score was negatively correlated with lower total scores of FSFI as well as arousal, orgasm, and satisfaction scores. The pain score was negatively correlated with the scores of the MMAS. The only predictors of FSFI total score were fatigue and visual disability. Visual disability was also a predictor of dysfunction in arousal and satisfaction domains, whereas spasticity in the lower limbs predicted sexual related pain. CONCLUSIONS: Sexual dysfunction in patients with NMOSD is strongly related to fatigue, depression, visual disability, and lower limbs spasticity. |
format | Online Article Text |
id | pubmed-8943970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89439702022-03-25 Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder ELmazny, Alaa Salama, Sara Hussein, Mona Elsebaie, Eman Hany Magdy, Rehab BMC Neurol Research BACKGROUND: Few research works have explored female sexual dysfunction (FSD) in patients with Neuromyelitis optica spectrum disorder (NMOSD) which remains an ignored disease symptom. This work aimed to describe the frequency, patterns, and predictors of FSD in a sample of newly diagnosed AQP4-ab seropositive NMOSD patients. METHODS: This case-control study was conducted on 28 seropositive NMOSD patients and 31 age matched healthy controls. All included patients were asked to privately fill and hand back the following questionnaires: female sexual function index questionnaire (FSFI), Beck depression inventory II (BDI) and fatigue severity scale (FSS). Also, Modified Modified Ashworth scale (MMAS) and Expanded disability status scale (EDSS) were applied to all included patients. RESULTS: NMOSD patients had significantly lower total FSFI scores and significantly higher BDI and FSS scores than controls (P < 0.001). FSS scores were negatively correlated with total scores of FSFI as well as desire, lubrication, orgasm, and satisfaction scores. BDI scores was negatively correlated with desire and orgasm scores. The uncorrected visual FS score was negatively correlated with lower total scores of FSFI as well as arousal, orgasm, and satisfaction scores. The pain score was negatively correlated with the scores of the MMAS. The only predictors of FSFI total score were fatigue and visual disability. Visual disability was also a predictor of dysfunction in arousal and satisfaction domains, whereas spasticity in the lower limbs predicted sexual related pain. CONCLUSIONS: Sexual dysfunction in patients with NMOSD is strongly related to fatigue, depression, visual disability, and lower limbs spasticity. BioMed Central 2022-03-24 /pmc/articles/PMC8943970/ /pubmed/35331161 http://dx.doi.org/10.1186/s12883-022-02648-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research ELmazny, Alaa Salama, Sara Hussein, Mona Elsebaie, Eman Hany Magdy, Rehab Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder |
title | Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder |
title_full | Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder |
title_fullStr | Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder |
title_full_unstemmed | Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder |
title_short | Female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder |
title_sort | female sexual dysfunction in newly diagnosed egyptian patients with neuromyelitis optica spectrum disorder |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943970/ https://www.ncbi.nlm.nih.gov/pubmed/35331161 http://dx.doi.org/10.1186/s12883-022-02648-8 |
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