Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease

INTRODUCTION: Neutrophil accumulation is a well-established feature of Alzheimer’s disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways. Neutrophils express high levels of the oxidant-generating enzyme myeloperoxidase (MPO),...

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Detalles Bibliográficos
Autores principales: Smyth, Leon C. D., Murray, Helen C., Hill, Madison, van Leeuwen, Eve, Highet, Blake, Magon, Nicholas J., Osanlouy, Mahyar, Mathiesen, Sophie N., Mockett, Bruce, Singh-Bains, Malvindar K., Morris, Vanessa K., Clarkson, Andrew N., Curtis, Maurice A., Abraham, Wickliffe C., Hughes, Stephanie M., Faull, Richard L. M., Kettle, Anthony J., Dragunow, Mike, Hampton, Mark B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944147/
https://www.ncbi.nlm.nih.gov/pubmed/35331340
http://dx.doi.org/10.1186/s40478-022-01347-2

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