An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

BACKGROUND: Supraphysiological hemodynamics are a recognized driver of platelet activation and thrombosis at high-grade stenosis and in blood contacting circulatory support devices. However, whether platelets mechano-sense hemodynamic parameters directly in free flow (in the absence of adhesion rece...

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Detalles Bibliográficos
Autores principales: Zainal Abidin, Nurul A., Poon, Eric K. W., Szydzik, Crispin, Timofeeva, Mariia, Akbaridoust, Farzan, Brazilek, Rose J., Tovar Lopez, Francisco J., Ma, Xiao, Lav, Chitrarth, Marusic, Ivan, Thompson, Philip E., Mitchell, Arnan, Ooi, Andrew S. H., Hamilton, Justin R., Nesbitt, Warwick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944166/
https://www.ncbi.nlm.nih.gov/pubmed/35331224
http://dx.doi.org/10.1186/s12915-022-01274-7

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