Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia

A growing number of gain-of-function (GOF) BK channelopathies have been identified in patients with epilepsy and movement disorders. Nevertheless, the underlying pathophysiology and corresponding therapeutics remain obscure. Here, we utilized a knock-in mouse model carrying human BK-D434G channelopa...

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Detalles Bibliográficos
Autores principales: Dong, Ping, Zhang, Yang, Hunanyan, Arsen S., Mikati, Mohamad A., Cui, Jianmin, Yang, Huanghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944272/
https://www.ncbi.nlm.nih.gov/pubmed/35286197
http://dx.doi.org/10.1073/pnas.2200140119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944272/
https://www.ncbi.nlm.nih.gov/pubmed/35286197
http://dx.doi.org/10.1073/pnas.2200140119

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