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Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation

Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase is closely associated with Alzheimer’s disease (AD). γ-secretase activating protein (GSAP) specifically promotes γ-secretase–mediated cleavage of APP. However, the underlying mechanism remains enigmatic. Here, we demonstrate that th...

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Detalles Bibliográficos
Autores principales:	Jin, Chen, Wang, Jiaoni, Wang, Yumeng, Jia, Bojun, Guo, Xuefei, Yang, Guanghui, Xu, Peng, Greengard, Paul, Zhou, Rui, Shi (施一公), Yigong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944281/ https://www.ncbi.nlm.nih.gov/pubmed/35298330 http://dx.doi.org/10.1073/pnas.2122292119

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