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Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944422/ https://www.ncbi.nlm.nih.gov/pubmed/35326875 http://dx.doi.org/10.3390/antibiotics11030412 |
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author | Skwarczynski, Mariusz Bashiri, Sahra Yuan, Ye Ziora, Zyta M. Nabil, Osama Masuda, Keita Khongkow, Mattaka Rimsueb, Natchanon Cabral, Horacio Ruktanonchai, Uracha Blaskovich, Mark A. T. Toth, Istvan |
author_facet | Skwarczynski, Mariusz Bashiri, Sahra Yuan, Ye Ziora, Zyta M. Nabil, Osama Masuda, Keita Khongkow, Mattaka Rimsueb, Natchanon Cabral, Horacio Ruktanonchai, Uracha Blaskovich, Mark A. T. Toth, Istvan |
author_sort | Skwarczynski, Mariusz |
collection | PubMed |
description | The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria. |
format | Online Article Text |
id | pubmed-8944422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89444222022-03-25 Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents Skwarczynski, Mariusz Bashiri, Sahra Yuan, Ye Ziora, Zyta M. Nabil, Osama Masuda, Keita Khongkow, Mattaka Rimsueb, Natchanon Cabral, Horacio Ruktanonchai, Uracha Blaskovich, Mark A. T. Toth, Istvan Antibiotics (Basel) Review The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria. MDPI 2022-03-18 /pmc/articles/PMC8944422/ /pubmed/35326875 http://dx.doi.org/10.3390/antibiotics11030412 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Skwarczynski, Mariusz Bashiri, Sahra Yuan, Ye Ziora, Zyta M. Nabil, Osama Masuda, Keita Khongkow, Mattaka Rimsueb, Natchanon Cabral, Horacio Ruktanonchai, Uracha Blaskovich, Mark A. T. Toth, Istvan Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents |
title | Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents |
title_full | Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents |
title_fullStr | Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents |
title_full_unstemmed | Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents |
title_short | Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents |
title_sort | antimicrobial activity enhancers: towards smart delivery of antimicrobial agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944422/ https://www.ncbi.nlm.nih.gov/pubmed/35326875 http://dx.doi.org/10.3390/antibiotics11030412 |
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