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Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents

The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of...

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Autores principales: Skwarczynski, Mariusz, Bashiri, Sahra, Yuan, Ye, Ziora, Zyta M., Nabil, Osama, Masuda, Keita, Khongkow, Mattaka, Rimsueb, Natchanon, Cabral, Horacio, Ruktanonchai, Uracha, Blaskovich, Mark A. T., Toth, Istvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944422/
https://www.ncbi.nlm.nih.gov/pubmed/35326875
http://dx.doi.org/10.3390/antibiotics11030412
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author Skwarczynski, Mariusz
Bashiri, Sahra
Yuan, Ye
Ziora, Zyta M.
Nabil, Osama
Masuda, Keita
Khongkow, Mattaka
Rimsueb, Natchanon
Cabral, Horacio
Ruktanonchai, Uracha
Blaskovich, Mark A. T.
Toth, Istvan
author_facet Skwarczynski, Mariusz
Bashiri, Sahra
Yuan, Ye
Ziora, Zyta M.
Nabil, Osama
Masuda, Keita
Khongkow, Mattaka
Rimsueb, Natchanon
Cabral, Horacio
Ruktanonchai, Uracha
Blaskovich, Mark A. T.
Toth, Istvan
author_sort Skwarczynski, Mariusz
collection PubMed
description The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria.
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spelling pubmed-89444222022-03-25 Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents Skwarczynski, Mariusz Bashiri, Sahra Yuan, Ye Ziora, Zyta M. Nabil, Osama Masuda, Keita Khongkow, Mattaka Rimsueb, Natchanon Cabral, Horacio Ruktanonchai, Uracha Blaskovich, Mark A. T. Toth, Istvan Antibiotics (Basel) Review The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria. MDPI 2022-03-18 /pmc/articles/PMC8944422/ /pubmed/35326875 http://dx.doi.org/10.3390/antibiotics11030412 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Skwarczynski, Mariusz
Bashiri, Sahra
Yuan, Ye
Ziora, Zyta M.
Nabil, Osama
Masuda, Keita
Khongkow, Mattaka
Rimsueb, Natchanon
Cabral, Horacio
Ruktanonchai, Uracha
Blaskovich, Mark A. T.
Toth, Istvan
Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
title Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
title_full Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
title_fullStr Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
title_full_unstemmed Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
title_short Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
title_sort antimicrobial activity enhancers: towards smart delivery of antimicrobial agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944422/
https://www.ncbi.nlm.nih.gov/pubmed/35326875
http://dx.doi.org/10.3390/antibiotics11030412
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