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Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

Carbapenems are important antibacterials and are both substrates and inhibitors of some β-lactamases. We report studies on the reaction of the unusual carbapenem biapenem, with the subclass B1 metallo-β-lactamases VIM-1 and VIM-2 and the class A serine-β-lactamase KPC-2. X-ray diffraction studies wi...

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Detalles Bibliográficos
Autores principales:	Lucic, Anka, Malla, Tika R., Calvopiña, Karina, Tooke, Catherine L., Brem, Jürgen, McDonough, Michael A., Spencer, James, Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944426/ https://www.ncbi.nlm.nih.gov/pubmed/35326858 http://dx.doi.org/10.3390/antibiotics11030396

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