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Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis
Thyroid and parathyroid surgery are considered clean procedures, with an incidence of surgical site infection (SSI) after thyroidectomy ranging from 0.09% to 2.9%. International guidelines do not recommend routine antibiotic prophylaxis (AP), while AP seems to be employed commonly in clinical practi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944446/ https://www.ncbi.nlm.nih.gov/pubmed/35326753 http://dx.doi.org/10.3390/antibiotics11030290 |
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author | Polistena, Andrea Prete, Francesco Paolo Avenia, Stefano Cavallaro, Giuseppe Di Meo, Giovanna Pasculli, Alessandro Rondelli, Fabio Sanguinetti, Alessandro Sgaramella, Lucia Ilaria Avenia, Nicola Testini, Mario Gurrado, Angela |
author_facet | Polistena, Andrea Prete, Francesco Paolo Avenia, Stefano Cavallaro, Giuseppe Di Meo, Giovanna Pasculli, Alessandro Rondelli, Fabio Sanguinetti, Alessandro Sgaramella, Lucia Ilaria Avenia, Nicola Testini, Mario Gurrado, Angela |
author_sort | Polistena, Andrea |
collection | PubMed |
description | Thyroid and parathyroid surgery are considered clean procedures, with an incidence of surgical site infection (SSI) after thyroidectomy ranging from 0.09% to 2.9%. International guidelines do not recommend routine antibiotic prophylaxis (AP), while AP seems to be employed commonly in clinical practice. The purpose of this systematic review is analyzing whether the postoperative SSI rate in thyroid and parathyroid surgery is altered by the practice of AP. We searched Pubmed, Scopus, the Cochrane Library, and Web of Science (WOS) for studies comparing AP to no preoperative antibiotics up to October 2021. Data on the SSI rate was evaluated and summarized as relative risks (RR) with 95% confidence intervals (95% CI). Risk of bias of studies were assessed with standard methods. Nine studies (4 RCTs and 5 nRCTs), including 8710 participants, were eligible for quantitative analysis. A meta-analysis showed that the SSI rate was not significantly different between AP and no preoperative antibiotics (SSI rate: 0.6% in AP vs. 2.4% in control group; RR 0.69, 0.43–1.10 95% CI, p = 0.13, I2 = 0%). A sensitivity analysis and subgroup analysis on RCTs were consistent with the main findings. Evidence of low quality supports that AP in thyroid and parathyroid surgery produce similar SSI rates as to the absence of perioperative antibiotics. |
format | Online Article Text |
id | pubmed-8944446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89444462022-03-25 Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis Polistena, Andrea Prete, Francesco Paolo Avenia, Stefano Cavallaro, Giuseppe Di Meo, Giovanna Pasculli, Alessandro Rondelli, Fabio Sanguinetti, Alessandro Sgaramella, Lucia Ilaria Avenia, Nicola Testini, Mario Gurrado, Angela Antibiotics (Basel) Systematic Review Thyroid and parathyroid surgery are considered clean procedures, with an incidence of surgical site infection (SSI) after thyroidectomy ranging from 0.09% to 2.9%. International guidelines do not recommend routine antibiotic prophylaxis (AP), while AP seems to be employed commonly in clinical practice. The purpose of this systematic review is analyzing whether the postoperative SSI rate in thyroid and parathyroid surgery is altered by the practice of AP. We searched Pubmed, Scopus, the Cochrane Library, and Web of Science (WOS) for studies comparing AP to no preoperative antibiotics up to October 2021. Data on the SSI rate was evaluated and summarized as relative risks (RR) with 95% confidence intervals (95% CI). Risk of bias of studies were assessed with standard methods. Nine studies (4 RCTs and 5 nRCTs), including 8710 participants, were eligible for quantitative analysis. A meta-analysis showed that the SSI rate was not significantly different between AP and no preoperative antibiotics (SSI rate: 0.6% in AP vs. 2.4% in control group; RR 0.69, 0.43–1.10 95% CI, p = 0.13, I2 = 0%). A sensitivity analysis and subgroup analysis on RCTs were consistent with the main findings. Evidence of low quality supports that AP in thyroid and parathyroid surgery produce similar SSI rates as to the absence of perioperative antibiotics. MDPI 2022-02-22 /pmc/articles/PMC8944446/ /pubmed/35326753 http://dx.doi.org/10.3390/antibiotics11030290 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Polistena, Andrea Prete, Francesco Paolo Avenia, Stefano Cavallaro, Giuseppe Di Meo, Giovanna Pasculli, Alessandro Rondelli, Fabio Sanguinetti, Alessandro Sgaramella, Lucia Ilaria Avenia, Nicola Testini, Mario Gurrado, Angela Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis |
title | Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis |
title_full | Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis |
title_fullStr | Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis |
title_short | Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis |
title_sort | effect of antibiotic prophylaxis on surgical site infection in thyroid and parathyroid surgery: a systematic review and meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944446/ https://www.ncbi.nlm.nih.gov/pubmed/35326753 http://dx.doi.org/10.3390/antibiotics11030290 |
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