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Venetoclax-Resistant MV4-11 Leukemic Cells Activate PI3K/AKT Pathway for Metabolic Reprogramming and Redox Adaptation for Survival

Venetoclax (ABT199) is a selective B-cell lymphoma 2 (BCL-2) inhibitor. The US FDA recently approved it to be used in combination with low-dose cytarabine or hypomethylating agents in acute myeloid leukemia (AML) or elderly patients non-eligible for chemotherapy. However, acquiring resistance to ven...

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Detalles Bibliográficos
Autores principales:	Alkhatabi, Hind A., Zohny, Samir F., Shait Mohammed, Mohammed Razeeth, Choudhry, Hani, Rehan, Mohd, Ahmad, Aamir, Ahmed, Farid, Khan, Mohammad Imran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944541/ https://www.ncbi.nlm.nih.gov/pubmed/35326111 http://dx.doi.org/10.3390/antiox11030461

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