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A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit

Defining optimal nutrition in animals and humans remains a main scientific challenge. The objective of the work was to develop a dynamic model of reactive oxygen species (ROS)–polyunsaturated fatty acid (PUFA)–antioxidant homeostasis using the rabbit as a model. The problem entity was to evaluate th...

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Autores principales: Mattioli, Simona, Dimauro, Corrado, Cesarani, Alberto, Dal Bosco, Alessandro, Bartolini, Desiree, Galli, Francesco, Migni, Anna, Sebastiani, Bartolomeo, Signorini, Cinzia, Oger, Camille, Collodel, Giulia, Castellini, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944554/
https://www.ncbi.nlm.nih.gov/pubmed/35326181
http://dx.doi.org/10.3390/antiox11030531
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author Mattioli, Simona
Dimauro, Corrado
Cesarani, Alberto
Dal Bosco, Alessandro
Bartolini, Desiree
Galli, Francesco
Migni, Anna
Sebastiani, Bartolomeo
Signorini, Cinzia
Oger, Camille
Collodel, Giulia
Castellini, Cesare
author_facet Mattioli, Simona
Dimauro, Corrado
Cesarani, Alberto
Dal Bosco, Alessandro
Bartolini, Desiree
Galli, Francesco
Migni, Anna
Sebastiani, Bartolomeo
Signorini, Cinzia
Oger, Camille
Collodel, Giulia
Castellini, Cesare
author_sort Mattioli, Simona
collection PubMed
description Defining optimal nutrition in animals and humans remains a main scientific challenge. The objective of the work was to develop a dynamic model of reactive oxygen species (ROS)–polyunsaturated fatty acid (PUFA)–antioxidant homeostasis using the rabbit as a model. The problem entity was to evaluate the main metabolites generated from interactions between traits included in the conceptual model and identified by three main sub–models: (i) ROS generation, (ii) PUFA oxidation and (iii) antioxidant defence. A mathematical model (VENSIM software) that consisted of molecular stocks (INPUTs, OUTPUTs), exchange flows (intermediate OUTPUTs) and process rates was developed. The calibration was performed by using standard experimental data (Experiment 1), whereas the validation was carried out in Experiments 2 and 3 by using supra–nutritional dietary inputs (VIT E+ and PUFA+). The accuracy of the models was measured using 95% confidence intervals. Analytical OUTPUTs (ROS, PUFA, Vit E, Ascorbic acid, Iso–/NeuroProstanes, Aldehydes) were well described by the standard model. There was also good accuracy for the VIT E+ scenario, whereas some compensatory rates (Kc1–Kc4) were added to assess body compensation when high levels of dietary PUFA were administered (Experiment 3). In conclusion, the model can be very useful for predicting the effects of dietary treatments on the redox homeostasis of rabbits.
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spelling pubmed-89445542022-03-25 A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit Mattioli, Simona Dimauro, Corrado Cesarani, Alberto Dal Bosco, Alessandro Bartolini, Desiree Galli, Francesco Migni, Anna Sebastiani, Bartolomeo Signorini, Cinzia Oger, Camille Collodel, Giulia Castellini, Cesare Antioxidants (Basel) Article Defining optimal nutrition in animals and humans remains a main scientific challenge. The objective of the work was to develop a dynamic model of reactive oxygen species (ROS)–polyunsaturated fatty acid (PUFA)–antioxidant homeostasis using the rabbit as a model. The problem entity was to evaluate the main metabolites generated from interactions between traits included in the conceptual model and identified by three main sub–models: (i) ROS generation, (ii) PUFA oxidation and (iii) antioxidant defence. A mathematical model (VENSIM software) that consisted of molecular stocks (INPUTs, OUTPUTs), exchange flows (intermediate OUTPUTs) and process rates was developed. The calibration was performed by using standard experimental data (Experiment 1), whereas the validation was carried out in Experiments 2 and 3 by using supra–nutritional dietary inputs (VIT E+ and PUFA+). The accuracy of the models was measured using 95% confidence intervals. Analytical OUTPUTs (ROS, PUFA, Vit E, Ascorbic acid, Iso–/NeuroProstanes, Aldehydes) were well described by the standard model. There was also good accuracy for the VIT E+ scenario, whereas some compensatory rates (Kc1–Kc4) were added to assess body compensation when high levels of dietary PUFA were administered (Experiment 3). In conclusion, the model can be very useful for predicting the effects of dietary treatments on the redox homeostasis of rabbits. MDPI 2022-03-10 /pmc/articles/PMC8944554/ /pubmed/35326181 http://dx.doi.org/10.3390/antiox11030531 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mattioli, Simona
Dimauro, Corrado
Cesarani, Alberto
Dal Bosco, Alessandro
Bartolini, Desiree
Galli, Francesco
Migni, Anna
Sebastiani, Bartolomeo
Signorini, Cinzia
Oger, Camille
Collodel, Giulia
Castellini, Cesare
A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit
title A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit
title_full A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit
title_fullStr A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit
title_full_unstemmed A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit
title_short A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit
title_sort dynamic model for estimating the interaction of ros–pufa–antioxidants in rabbit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944554/
https://www.ncbi.nlm.nih.gov/pubmed/35326181
http://dx.doi.org/10.3390/antiox11030531
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