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Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation

Nanotechnology provides solutions by combining the fields of textiles and medicine to prevent infectious microbial spread. Our study aimed to evaluate the antimicrobial activity of nanofiber sheets incorporated with a well-known antibiotic, ceftriaxone. It is a third-generation antibiotic that belon...

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Autores principales: Youdhestar, Mahar, Faraz Khan, Das, Gotam, Tajammul, Ayesha, Ahmed, Farooq, Khatri, Muzamil, Khan, Sheeraz, Khatri, Zeeshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944567/
https://www.ncbi.nlm.nih.gov/pubmed/35326815
http://dx.doi.org/10.3390/antibiotics11030352
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author Youdhestar,
Mahar, Faraz Khan
Das, Gotam
Tajammul, Ayesha
Ahmed, Farooq
Khatri, Muzamil
Khan, Sheeraz
Khatri, Zeeshan
author_facet Youdhestar,
Mahar, Faraz Khan
Das, Gotam
Tajammul, Ayesha
Ahmed, Farooq
Khatri, Muzamil
Khan, Sheeraz
Khatri, Zeeshan
author_sort Youdhestar,
collection PubMed
description Nanotechnology provides solutions by combining the fields of textiles and medicine to prevent infectious microbial spread. Our study aimed to evaluate the antimicrobial activity of nanofiber sheets incorporated with a well-known antibiotic, ceftriaxone. It is a third-generation antibiotic that belongs to the cephalosporin group. Different percentages (0, 5%, 10%, 15%, and 20%; based on polymer wt%) of ceftriaxone were incorporated with a polymer such as polyvinyl alcohol (PVA) via electrospinning to fabricate nanofiber sheets. The Kirby-Bauer method was used to evaluate the antimicrobial susceptibility of the nanofiber sheets using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). For the characterization of the nanofiber sheets incorporated with the drug, several techniques were used, such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Our results showed that the nanofiber sheets containing ceftriaxone had potential inhibitory activity against E. coli and S. aureus as they had inhibition zones of approximately 20–25 mm on Mueller-Hinton-agar-containing plates. In conclusion, our nanofiber sheets fabricated with ceftriaxone have potential inhibitory effects against bacteria and can be used as a dressing to treat wounds in hospitals and for other biomedical applications.
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spelling pubmed-89445672022-03-25 Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation Youdhestar, Mahar, Faraz Khan Das, Gotam Tajammul, Ayesha Ahmed, Farooq Khatri, Muzamil Khan, Sheeraz Khatri, Zeeshan Antibiotics (Basel) Article Nanotechnology provides solutions by combining the fields of textiles and medicine to prevent infectious microbial spread. Our study aimed to evaluate the antimicrobial activity of nanofiber sheets incorporated with a well-known antibiotic, ceftriaxone. It is a third-generation antibiotic that belongs to the cephalosporin group. Different percentages (0, 5%, 10%, 15%, and 20%; based on polymer wt%) of ceftriaxone were incorporated with a polymer such as polyvinyl alcohol (PVA) via electrospinning to fabricate nanofiber sheets. The Kirby-Bauer method was used to evaluate the antimicrobial susceptibility of the nanofiber sheets using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). For the characterization of the nanofiber sheets incorporated with the drug, several techniques were used, such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Our results showed that the nanofiber sheets containing ceftriaxone had potential inhibitory activity against E. coli and S. aureus as they had inhibition zones of approximately 20–25 mm on Mueller-Hinton-agar-containing plates. In conclusion, our nanofiber sheets fabricated with ceftriaxone have potential inhibitory effects against bacteria and can be used as a dressing to treat wounds in hospitals and for other biomedical applications. MDPI 2022-03-07 /pmc/articles/PMC8944567/ /pubmed/35326815 http://dx.doi.org/10.3390/antibiotics11030352 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Youdhestar,
Mahar, Faraz Khan
Das, Gotam
Tajammul, Ayesha
Ahmed, Farooq
Khatri, Muzamil
Khan, Sheeraz
Khatri, Zeeshan
Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation
title Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation
title_full Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation
title_fullStr Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation
title_full_unstemmed Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation
title_short Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation
title_sort fabrication of ceftriaxone-loaded cellulose acetate and polyvinyl alcohol nanofibers and their antibacterial evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944567/
https://www.ncbi.nlm.nih.gov/pubmed/35326815
http://dx.doi.org/10.3390/antibiotics11030352
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