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Social reactivation of fear engrams enhances memory recall

For group-living animals, the social environment provides salient experience that can weaken or strengthen aspects of cognition such as memory recall. Although the cellular substrates of individually acquired fear memories in the dentate gyrus (DG) and basolateral amygdala (BLA) have been well-studi...

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Autores principales: Finkelstein, Abby Basya, Leblanc, Héloïse, Cole, Rebecca H., Gallerani, Troy, Vieira, Anahita, Zaki, Yosif, Ramirez, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944571/
https://www.ncbi.nlm.nih.gov/pubmed/35286206
http://dx.doi.org/10.1073/pnas.2114230119
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author Finkelstein, Abby Basya
Leblanc, Héloïse
Cole, Rebecca H.
Gallerani, Troy
Vieira, Anahita
Zaki, Yosif
Ramirez, Steve
author_facet Finkelstein, Abby Basya
Leblanc, Héloïse
Cole, Rebecca H.
Gallerani, Troy
Vieira, Anahita
Zaki, Yosif
Ramirez, Steve
author_sort Finkelstein, Abby Basya
collection PubMed
description For group-living animals, the social environment provides salient experience that can weaken or strengthen aspects of cognition such as memory recall. Although the cellular substrates of individually acquired fear memories in the dentate gyrus (DG) and basolateral amygdala (BLA) have been well-studied and recent work has revealed circuit mechanisms underlying the encoding of social experience, the processes by which social experience interacts with an individual’s memories to alter recall remain unknown. Here we show that stressful social experiences enhance the recall of previously acquired fear memories in male but not female mice, and that social buffering of conspecifics’ distress blocks this enhancement. Activity-dependent tagging of cells in the DG during fear learning revealed that these ensembles were endogenously reactivated during the social experiences in males, even after extinction. These reactivated cells were shown to be functional components of engrams, as optogenetic stimulation of the cells active during the social experience in previously fear-conditioned and not naïve animals was sufficient to drive fear-related behaviors. Taken together, our findings suggest that social experiences can reactivate preexisting engrams to thereby strengthen discrete memories.
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spelling pubmed-89445712022-09-14 Social reactivation of fear engrams enhances memory recall Finkelstein, Abby Basya Leblanc, Héloïse Cole, Rebecca H. Gallerani, Troy Vieira, Anahita Zaki, Yosif Ramirez, Steve Proc Natl Acad Sci U S A Biological Sciences For group-living animals, the social environment provides salient experience that can weaken or strengthen aspects of cognition such as memory recall. Although the cellular substrates of individually acquired fear memories in the dentate gyrus (DG) and basolateral amygdala (BLA) have been well-studied and recent work has revealed circuit mechanisms underlying the encoding of social experience, the processes by which social experience interacts with an individual’s memories to alter recall remain unknown. Here we show that stressful social experiences enhance the recall of previously acquired fear memories in male but not female mice, and that social buffering of conspecifics’ distress blocks this enhancement. Activity-dependent tagging of cells in the DG during fear learning revealed that these ensembles were endogenously reactivated during the social experiences in males, even after extinction. These reactivated cells were shown to be functional components of engrams, as optogenetic stimulation of the cells active during the social experience in previously fear-conditioned and not naïve animals was sufficient to drive fear-related behaviors. Taken together, our findings suggest that social experiences can reactivate preexisting engrams to thereby strengthen discrete memories. National Academy of Sciences 2022-03-14 2022-03-22 /pmc/articles/PMC8944571/ /pubmed/35286206 http://dx.doi.org/10.1073/pnas.2114230119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Finkelstein, Abby Basya
Leblanc, Héloïse
Cole, Rebecca H.
Gallerani, Troy
Vieira, Anahita
Zaki, Yosif
Ramirez, Steve
Social reactivation of fear engrams enhances memory recall
title Social reactivation of fear engrams enhances memory recall
title_full Social reactivation of fear engrams enhances memory recall
title_fullStr Social reactivation of fear engrams enhances memory recall
title_full_unstemmed Social reactivation of fear engrams enhances memory recall
title_short Social reactivation of fear engrams enhances memory recall
title_sort social reactivation of fear engrams enhances memory recall
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944571/
https://www.ncbi.nlm.nih.gov/pubmed/35286206
http://dx.doi.org/10.1073/pnas.2114230119
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