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Contiguously hydrophobic sequences are functionally significant throughout the human exome
Hydrophobic interactions have long been established as essential for stabilizing structured proteins as well as drivers of aggregation, but the impact of hydrophobicity on the functional significance of sequence variants has rarely been considered in a genome-wide context. Here we test the role of h...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944643/ https://www.ncbi.nlm.nih.gov/pubmed/35294280 http://dx.doi.org/10.1073/pnas.2116267119 |