Parkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein–induced changes in maturation and immune reactive properties

Limited evidence has shed light on how aSYN proteins affect the oligodendrocyte phenotype and pathogenesis in synucleinopathies that include Parkinson’s disease (PD) and multiple system atrophy (MSA). Here, we investigated early transcriptomic changes within PD and MSA O4(+) oligodendrocyte lineage...

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Detalles Bibliográficos
Autores principales: Azevedo, Carla, Teku, Gabriel, Pomeshchik, Yuriy, Reyes, Juan F., Chumarina, Margarita, Russ, Kaspar, Savchenko, Ekaterina, Hammarberg, Anna, Lamas, Nuno Jorge, Collin, Anna, Gouras, Gunnar K., Klementieva, Oxana, Hallbeck, Martin, Taipa, Ricardo, Vihinen, Mauno, Roybon, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944747/
https://www.ncbi.nlm.nih.gov/pubmed/35294277
http://dx.doi.org/10.1073/pnas.2111405119

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