Cargando…

Peripheral Aβ acts as a negative modulator of insulin secretion

Type 2 diabetes mellitus is known to be a risk factor for Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. In AD, the cerebral accumulation of amyloid β (Aβ) triggers a pathological cascade leading to neurodegeneration. Plasma Aβ levels are thought to reflect the brain amyloid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shigemori, Keiko, Nomura, Sachiko, Umeda, Tomohiro, Takeda, Shuko, Tomiyama, Takami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944757/ https://www.ncbi.nlm.nih.gov/pubmed/35290109 http://dx.doi.org/10.1073/pnas.2117723119

Ejemplares similares

Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice
por: Umeda, Tomohiro, et al.
Publicado: (2022)

Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination – A Preclinical Study in Model Mice
por: Umeda, Tomohiro, et al.
Publicado: (2021)

C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice
por: Hatanaka, Yukari, et al.
Publicado: (2022)

Functional screening system for yeast-secreted peptides acting on G-protein coupled receptors
por: Shigemori, Tomohiro, et al.
Publicado: (2015)

Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers
por: Umeda, Tomohiro, et al.
Publicado: (2021)

Insulin secretion hot spots in pancreatic β cells as secreting adhesions
por: Fye, Margret A., et al.
Publicado: (2023)

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
por: Umeda, Tomohiro, et al.
Publicado: (2015)

Propofol inhibits stromatoxin-1-sensitive voltage-dependent K(+) channels in pancreatic β-cells and enhances insulin secretion
por: Kusunoki, Munenori, et al.
Publicado: (2019)

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells
por: Arous, Caroline, et al.
Publicado: (2021)

Intranasal rifampicin for Alzheimer's disease prevention
por: Umeda, Tomohiro, et al.
Publicado: (2018)

A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion
por: Yang, Kisuk, et al.
Publicado: (2021)

The role of peripheral β-amyloid in insulin resistance, insulin secretion, and prediabetes: in vitro and population-based studies
por: Xu, Zihui, et al.
Publicado: (2023)

Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots
por: Trogden, Kathryn P, et al.
Publicado: (2021)

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice
por: Umeda, Tomohiro, et al.
Publicado: (2015)

How Metformin Acts in PCOS Pregnant Women: Insights into insulin secretion and peripheral action at each trimester of gestation
por: Romualdi, Daniela, et al.
Publicado: (2013)

Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic β-Cells
por: Miyazaki, Satsuki, et al.
Publicado: (2010)

Insulin-like growth factor-1 is a negative modulator of glucagon secretion
por: Mancuso, Elettra, et al.
Publicado: (2017)

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION
por: Liu, Ying, et al.
Publicado: (2015)

A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion
por: Qiao, Jingting, et al.
Publicado: (2022)

Nitric oxide interacts with cholinoceptors to modulate insulin secretion by pancreatic β cells
por: Mussa, Bashair M., et al.
Publicado: (2020)

Regulation of insulin secretion by the post-translational modifications
por: Yang, Chunhua, et al.
Publicado: (2023)

Control of the negative IRES trans-acting factor KHSRP by ubiquitination
por: Kung, Yu-An, et al.
Publicado: (2017)

ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process
por: Ferreira, Sandra M., et al.
Publicado: (2020)

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation
por: Paulmann, Nils, et al.
Publicado: (2009)

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain
por: Amano, Akiko, et al.
Publicado: (2023)

APOE expression and secretion are modulated by mitochondrial dysfunction
por: Wynne, Meghan E, et al.
Publicado: (2023)

An aptamer agonist of the insulin receptor acts as a positive or negative allosteric modulator, depending on its concentration
por: Yunn, Na-Oh, et al.
Publicado: (2022)

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport
por: Wijesekara, Nadeeja, et al.
Publicado: (2021)

SUN-658 CHL1 Increases Insulin Secretion&Negatively Regulates the Poliferation of Pancreatic β Cell
por: Yang, Tao, et al.
Publicado: (2020)

Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells
por: Udagawa, Haruhide, et al.
Publicado: (2023)

Collagen IV-β1-Integrin Influences INS-1 Cell Insulin Secretion via Enhanced SNARE Protein Expression
por: Barillaro, Malina, et al.
Publicado: (2022)

Influence of Flavonoids on Mechanism of Modulation of Insulin Secretion
por: Soares, Juliana Mikaelly Dias, et al.
Publicado: (2017)

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity
por: Panayiotou, Richard, et al.
Publicado: (2016)

Peripheral Dopamine Directly Acts on Insulin-Sensitive Tissues to Regulate Insulin Signaling and Metabolic Function
por: Tavares, Gabriela, et al.
Publicado: (2021)

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR
por: Guo, Jing Hui, et al.
Publicado: (2014)

Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion
por: Szczerbinska, Iwona, et al.
Publicado: (2022)

A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth
por: Kim, Hee Young, et al.
Publicado: (2014)

Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from β-Lactoglobulin Secreted by Lactococcus lactis
por: Shigemori, Suguru, et al.
Publicado: (2014)

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans
por: Martinez, Bryan A, et al.
Publicado: (2020)

Optogenetic regulation of insulin secretion in pancreatic β-cells
por: Zhang, Fan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mgd717619am95catnsf5u3vc3s