Potential Role of Protocatechuic Acid as Natural Feed Additives in Farm Animal Production

SIMPLE SUMMARY: Protocatechuic acid (PCA) is a phenolic-rich compound that exists in natural plants. Many in vitro studies have reported its antioxidant, anti-inflammatory, anti-microbial properties. Although the health-promoting effects of PCA have been established in human medicine, the applications of PCA as natural feed additives on farm animal production still need to be re-investigated. Therefore, the aim of the review study was to gather research information on PCA to better our understanding of the practical uses of those natural antioxidant-rich feed additives in animal fodder. ABSTRACT: Restriction on using antibiotics in animal feed that generates demand for antibiotics alternatives in animal breeding. Providing safe food to humans free from the residual effects of antibiotics is a great challenge to animal producers and food-producing industry owners. Medicinal plants and their extracts as feed supplements have been used to promote the growth and health of farm animals for centuries. Protocatechuic acid (PCA) is a phenolic compound that originated from natural plants. For years, the health-promoting role of PCA has been becoming an attraction of research in nutrition and pharmacy. Thus, it can be used as an active natural feed additive while synthetic antibiotics are illegal to use in animal breeding. However, the practical application of PCA in view of dosages in animal nutrition, together with its mode of action on animal health, is not well known. In this regard, this review study has explored the mode of action of PCA and the feasibility of using those compounds in animal nutrition. This review study concludes that phenolic-rich protocatechuic acid as a natural feed additive may be useful in enhancing antioxidant status, immune function, antimicrobial, intestinal health and growth performance of farm animals.