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The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model

The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following...

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Autores principales: Santamarina, Aline Boveto, Moraes, Ruan Carlos Macêdo, Nehmi Filho, Victor, Murata, Gilson Masahiro, de Freitas, Jéssica Alves, de Miranda, Danielle Araujo, Cerqueira, Anderson Romério Azevedo, Costa, Soraia Katia Pereira, Ferreira, Ana Flávia Fernandes, Britto, Luiz Roberto, de Camargo, Juliana Alves, Rodrigues de Oliveira, Daniela, de Jesus, Flavia Neto, Otoch, José Pinhata, Pessoa, Ana Flávia Marçal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944780/
https://www.ncbi.nlm.nih.gov/pubmed/35326098
http://dx.doi.org/10.3390/antiox11030447
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author Santamarina, Aline Boveto
Moraes, Ruan Carlos Macêdo
Nehmi Filho, Victor
Murata, Gilson Masahiro
de Freitas, Jéssica Alves
de Miranda, Danielle Araujo
Cerqueira, Anderson Romério Azevedo
Costa, Soraia Katia Pereira
Ferreira, Ana Flávia Fernandes
Britto, Luiz Roberto
de Camargo, Juliana Alves
Rodrigues de Oliveira, Daniela
de Jesus, Flavia Neto
Otoch, José Pinhata
Pessoa, Ana Flávia Marçal
author_facet Santamarina, Aline Boveto
Moraes, Ruan Carlos Macêdo
Nehmi Filho, Victor
Murata, Gilson Masahiro
de Freitas, Jéssica Alves
de Miranda, Danielle Araujo
Cerqueira, Anderson Romério Azevedo
Costa, Soraia Katia Pereira
Ferreira, Ana Flávia Fernandes
Britto, Luiz Roberto
de Camargo, Juliana Alves
Rodrigues de Oliveira, Daniela
de Jesus, Flavia Neto
Otoch, José Pinhata
Pessoa, Ana Flávia Marçal
author_sort Santamarina, Aline Boveto
collection PubMed
description The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four weeks of the diet (28 consecutive days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene expression in these groups of mice. After four weeks of supplementation, only the new nutraceutical group (HFD + Supplemented) experienced reduced fasting glycemia, insulin, HOMA index, HOMA-β, dyslipidemia, ectopic fat deposition, and hepatic fibrosis levels. Additionally, the PPARγ coactivator 1 α (Pgc-1α), interleukin-6 (Il-6), and interleukin-10 (Il-10) gene expression were augmented, while hepatic steatosis decreased and liver parenchyma was recovered. The glutathione-S-transferase activity status was found to be modulated by the supplement. We discovered that the new nutraceutical was able to improve insulin resistance and hepatic steatosis mainly by regulating IL-6, IL-10, and Pgc-1α gene expression.
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spelling pubmed-89447802022-03-25 The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model Santamarina, Aline Boveto Moraes, Ruan Carlos Macêdo Nehmi Filho, Victor Murata, Gilson Masahiro de Freitas, Jéssica Alves de Miranda, Danielle Araujo Cerqueira, Anderson Romério Azevedo Costa, Soraia Katia Pereira Ferreira, Ana Flávia Fernandes Britto, Luiz Roberto de Camargo, Juliana Alves Rodrigues de Oliveira, Daniela de Jesus, Flavia Neto Otoch, José Pinhata Pessoa, Ana Flávia Marçal Antioxidants (Basel) Article The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four weeks of the diet (28 consecutive days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene expression in these groups of mice. After four weeks of supplementation, only the new nutraceutical group (HFD + Supplemented) experienced reduced fasting glycemia, insulin, HOMA index, HOMA-β, dyslipidemia, ectopic fat deposition, and hepatic fibrosis levels. Additionally, the PPARγ coactivator 1 α (Pgc-1α), interleukin-6 (Il-6), and interleukin-10 (Il-10) gene expression were augmented, while hepatic steatosis decreased and liver parenchyma was recovered. The glutathione-S-transferase activity status was found to be modulated by the supplement. We discovered that the new nutraceutical was able to improve insulin resistance and hepatic steatosis mainly by regulating IL-6, IL-10, and Pgc-1α gene expression. MDPI 2022-02-23 /pmc/articles/PMC8944780/ /pubmed/35326098 http://dx.doi.org/10.3390/antiox11030447 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Santamarina, Aline Boveto
Moraes, Ruan Carlos Macêdo
Nehmi Filho, Victor
Murata, Gilson Masahiro
de Freitas, Jéssica Alves
de Miranda, Danielle Araujo
Cerqueira, Anderson Romério Azevedo
Costa, Soraia Katia Pereira
Ferreira, Ana Flávia Fernandes
Britto, Luiz Roberto
de Camargo, Juliana Alves
Rodrigues de Oliveira, Daniela
de Jesus, Flavia Neto
Otoch, José Pinhata
Pessoa, Ana Flávia Marçal
The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
title The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
title_full The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
title_fullStr The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
title_full_unstemmed The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
title_short The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
title_sort symbiotic effect of a new nutraceutical with yeast β-glucan, prebiotics, minerals, and silybum marianum (silymarin) for recovering metabolic homeostasis via pgc-1α, il-6, and il-10 gene expression in a type-2 diabetes obesity model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944780/
https://www.ncbi.nlm.nih.gov/pubmed/35326098
http://dx.doi.org/10.3390/antiox11030447
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