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Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery

Pediatric cardiac surgery induces an increased oxidative stress (OS) response. Increased OS is associated with poor neurologic outcomes in neonatal populations with similar patterns of brain injury. We investigated OS and brain injury in infants undergoing heart surgery. Patients 6 months or younger...

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Autores principales: Cañizo Vázquez, Débora, Hadley, Stephanie M., Pérez Ordóñez, Marta, Lopez-Abad, Miriam, Valls, Anna, Viñals, Marta López, Moscoso, Bosco A., Benito Fernandez, Sergio, Camprubí-Camprubí, Marta, Sanchez-de-Toledo, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944849/
https://www.ncbi.nlm.nih.gov/pubmed/35326139
http://dx.doi.org/10.3390/antiox11030489
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author Cañizo Vázquez, Débora
Hadley, Stephanie M.
Pérez Ordóñez, Marta
Lopez-Abad, Miriam
Valls, Anna
Viñals, Marta López
Moscoso, Bosco A.
Benito Fernandez, Sergio
Camprubí-Camprubí, Marta
Sanchez-de-Toledo, Joan
author_facet Cañizo Vázquez, Débora
Hadley, Stephanie M.
Pérez Ordóñez, Marta
Lopez-Abad, Miriam
Valls, Anna
Viñals, Marta López
Moscoso, Bosco A.
Benito Fernandez, Sergio
Camprubí-Camprubí, Marta
Sanchez-de-Toledo, Joan
author_sort Cañizo Vázquez, Débora
collection PubMed
description Pediatric cardiac surgery induces an increased oxidative stress (OS) response. Increased OS is associated with poor neurologic outcomes in neonatal populations with similar patterns of brain injury. We investigated OS and brain injury in infants undergoing heart surgery. Patients 6 months or younger, undergoing cardiac surgery with or without cardiopulmonary bypass (CPB), were included in this prospective, observational study. Patients were divided into infant (30 days–6 months) and neonatal (<30 days) groups for analysis. Urine OS biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) was quantified pre-surgery and at 0 and 24 h post-surgery. A serum brain damage biomarker S100B protein was also measured pre-surgery and at 0 and 72 h post-surgery. Amplitude-integrated electroencephalography during surgery was analyzed. Neuropsychological evaluation using the Bayley III or Vineland test was performed in all patients at 24 months of age. Sixty-two patients were included, 44 of whom underwent follow-up neurologic evaluation. 8-iso-PGF2α and S100B levels were increased after surgery. Postoperative levels of S100B were positively correlated with 8-iso-PGF2α levels 24 h after surgery (rho = 0.5224; p = 0.0261). There was also a correlation between immediate post-surgery levels of 8-iso-PGF2α and intra-surgery seizure burden (rho = 0.4285, p = 0.0205). Patients with an abnormal neurological evaluation had increased levels of S100B 72 h after surgery (p = 0.048). 8-iso-PGF2α levels 24 h after surgery were also related to abnormal neurologic outcomes. Levels of 8-iso-PGF2α following pediatric cardiac surgery are associated with several indicators of brain injury including brain damage biomarkers, intra-operative seizures, and abnormal neurological evaluation at follow-up, suggesting the importance of oxidative stress response in the origin of brain damage in this population.
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spelling pubmed-89448492022-03-25 Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery Cañizo Vázquez, Débora Hadley, Stephanie M. Pérez Ordóñez, Marta Lopez-Abad, Miriam Valls, Anna Viñals, Marta López Moscoso, Bosco A. Benito Fernandez, Sergio Camprubí-Camprubí, Marta Sanchez-de-Toledo, Joan Antioxidants (Basel) Article Pediatric cardiac surgery induces an increased oxidative stress (OS) response. Increased OS is associated with poor neurologic outcomes in neonatal populations with similar patterns of brain injury. We investigated OS and brain injury in infants undergoing heart surgery. Patients 6 months or younger, undergoing cardiac surgery with or without cardiopulmonary bypass (CPB), were included in this prospective, observational study. Patients were divided into infant (30 days–6 months) and neonatal (<30 days) groups for analysis. Urine OS biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) was quantified pre-surgery and at 0 and 24 h post-surgery. A serum brain damage biomarker S100B protein was also measured pre-surgery and at 0 and 72 h post-surgery. Amplitude-integrated electroencephalography during surgery was analyzed. Neuropsychological evaluation using the Bayley III or Vineland test was performed in all patients at 24 months of age. Sixty-two patients were included, 44 of whom underwent follow-up neurologic evaluation. 8-iso-PGF2α and S100B levels were increased after surgery. Postoperative levels of S100B were positively correlated with 8-iso-PGF2α levels 24 h after surgery (rho = 0.5224; p = 0.0261). There was also a correlation between immediate post-surgery levels of 8-iso-PGF2α and intra-surgery seizure burden (rho = 0.4285, p = 0.0205). Patients with an abnormal neurological evaluation had increased levels of S100B 72 h after surgery (p = 0.048). 8-iso-PGF2α levels 24 h after surgery were also related to abnormal neurologic outcomes. Levels of 8-iso-PGF2α following pediatric cardiac surgery are associated with several indicators of brain injury including brain damage biomarkers, intra-operative seizures, and abnormal neurological evaluation at follow-up, suggesting the importance of oxidative stress response in the origin of brain damage in this population. MDPI 2022-02-28 /pmc/articles/PMC8944849/ /pubmed/35326139 http://dx.doi.org/10.3390/antiox11030489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cañizo Vázquez, Débora
Hadley, Stephanie M.
Pérez Ordóñez, Marta
Lopez-Abad, Miriam
Valls, Anna
Viñals, Marta López
Moscoso, Bosco A.
Benito Fernandez, Sergio
Camprubí-Camprubí, Marta
Sanchez-de-Toledo, Joan
Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery
title Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery
title_full Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery
title_fullStr Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery
title_full_unstemmed Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery
title_short Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery
title_sort oxidative stress and indicators of brain damage following pediatric heart surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944849/
https://www.ncbi.nlm.nih.gov/pubmed/35326139
http://dx.doi.org/10.3390/antiox11030489
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