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Circular RNA ITCH: An Emerging Multifunctional Regulator
In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerou...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944968/ https://www.ncbi.nlm.nih.gov/pubmed/35327551 http://dx.doi.org/10.3390/biom12030359 |
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author | Su, Kaixin Yi, Qiao Dai, Xiaohan Liu, Ousheng |
author_facet | Su, Kaixin Yi, Qiao Dai, Xiaohan Liu, Ousheng |
author_sort | Su, Kaixin |
collection | PubMed |
description | In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target. |
format | Online Article Text |
id | pubmed-8944968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89449682022-03-25 Circular RNA ITCH: An Emerging Multifunctional Regulator Su, Kaixin Yi, Qiao Dai, Xiaohan Liu, Ousheng Biomolecules Review In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target. MDPI 2022-02-24 /pmc/articles/PMC8944968/ /pubmed/35327551 http://dx.doi.org/10.3390/biom12030359 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Su, Kaixin Yi, Qiao Dai, Xiaohan Liu, Ousheng Circular RNA ITCH: An Emerging Multifunctional Regulator |
title | Circular RNA ITCH: An Emerging Multifunctional Regulator |
title_full | Circular RNA ITCH: An Emerging Multifunctional Regulator |
title_fullStr | Circular RNA ITCH: An Emerging Multifunctional Regulator |
title_full_unstemmed | Circular RNA ITCH: An Emerging Multifunctional Regulator |
title_short | Circular RNA ITCH: An Emerging Multifunctional Regulator |
title_sort | circular rna itch: an emerging multifunctional regulator |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944968/ https://www.ncbi.nlm.nih.gov/pubmed/35327551 http://dx.doi.org/10.3390/biom12030359 |
work_keys_str_mv | AT sukaixin circularrnaitchanemergingmultifunctionalregulator AT yiqiao circularrnaitchanemergingmultifunctionalregulator AT daixiaohan circularrnaitchanemergingmultifunctionalregulator AT liuousheng circularrnaitchanemergingmultifunctionalregulator |