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Circular RNA ITCH: An Emerging Multifunctional Regulator

In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerou...

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Detalles Bibliográficos
Autores principales: Su, Kaixin, Yi, Qiao, Dai, Xiaohan, Liu, Ousheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944968/
https://www.ncbi.nlm.nih.gov/pubmed/35327551
http://dx.doi.org/10.3390/biom12030359
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author Su, Kaixin
Yi, Qiao
Dai, Xiaohan
Liu, Ousheng
author_facet Su, Kaixin
Yi, Qiao
Dai, Xiaohan
Liu, Ousheng
author_sort Su, Kaixin
collection PubMed
description In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target.
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spelling pubmed-89449682022-03-25 Circular RNA ITCH: An Emerging Multifunctional Regulator Su, Kaixin Yi, Qiao Dai, Xiaohan Liu, Ousheng Biomolecules Review In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target. MDPI 2022-02-24 /pmc/articles/PMC8944968/ /pubmed/35327551 http://dx.doi.org/10.3390/biom12030359 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Su, Kaixin
Yi, Qiao
Dai, Xiaohan
Liu, Ousheng
Circular RNA ITCH: An Emerging Multifunctional Regulator
title Circular RNA ITCH: An Emerging Multifunctional Regulator
title_full Circular RNA ITCH: An Emerging Multifunctional Regulator
title_fullStr Circular RNA ITCH: An Emerging Multifunctional Regulator
title_full_unstemmed Circular RNA ITCH: An Emerging Multifunctional Regulator
title_short Circular RNA ITCH: An Emerging Multifunctional Regulator
title_sort circular rna itch: an emerging multifunctional regulator
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944968/
https://www.ncbi.nlm.nih.gov/pubmed/35327551
http://dx.doi.org/10.3390/biom12030359
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AT yiqiao circularrnaitchanemergingmultifunctionalregulator
AT daixiaohan circularrnaitchanemergingmultifunctionalregulator
AT liuousheng circularrnaitchanemergingmultifunctionalregulator