Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches

Gastric cancer (GC) remains one of the most common deadly malignancies worldwide. Recently, several targeted therapeutics for treating unresectable or metastatic GC have been developed. Comprehensive characterization of the molecular profile and of the tumor immune microenvironment of GC has allowed...

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Autores principales: Choi, Sangjoon, Park, Sujin, Kim, Hyunjin, Kang, So Young, Ahn, Soomin, Kim, Kyoung-Mee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945014/
https://www.ncbi.nlm.nih.gov/pubmed/35327345
http://dx.doi.org/10.3390/biomedicines10030543
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author Choi, Sangjoon
Park, Sujin
Kim, Hyunjin
Kang, So Young
Ahn, Soomin
Kim, Kyoung-Mee
author_facet Choi, Sangjoon
Park, Sujin
Kim, Hyunjin
Kang, So Young
Ahn, Soomin
Kim, Kyoung-Mee
author_sort Choi, Sangjoon
collection PubMed
description Gastric cancer (GC) remains one of the most common deadly malignancies worldwide. Recently, several targeted therapeutics for treating unresectable or metastatic GC have been developed. Comprehensive characterization of the molecular profile and of the tumor immune microenvironment of GC has allowed researchers to explore promising biomarkers for GC treatment and has enabled a new paradigm in precision-targeted immunotherapy. In this article, we review established and promising new biomarkers relevant in GC, with a focus on their clinical implications, diagnostic methods, and the efficacy of targeted agents.
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spelling pubmed-89450142022-03-25 Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches Choi, Sangjoon Park, Sujin Kim, Hyunjin Kang, So Young Ahn, Soomin Kim, Kyoung-Mee Biomedicines Review Gastric cancer (GC) remains one of the most common deadly malignancies worldwide. Recently, several targeted therapeutics for treating unresectable or metastatic GC have been developed. Comprehensive characterization of the molecular profile and of the tumor immune microenvironment of GC has allowed researchers to explore promising biomarkers for GC treatment and has enabled a new paradigm in precision-targeted immunotherapy. In this article, we review established and promising new biomarkers relevant in GC, with a focus on their clinical implications, diagnostic methods, and the efficacy of targeted agents. MDPI 2022-02-24 /pmc/articles/PMC8945014/ /pubmed/35327345 http://dx.doi.org/10.3390/biomedicines10030543 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Choi, Sangjoon
Park, Sujin
Kim, Hyunjin
Kang, So Young
Ahn, Soomin
Kim, Kyoung-Mee
Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches
title Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches
title_full Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches
title_fullStr Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches
title_full_unstemmed Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches
title_short Gastric Cancer: Mechanisms, Biomarkers, and Therapeutic Approaches
title_sort gastric cancer: mechanisms, biomarkers, and therapeutic approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945014/
https://www.ncbi.nlm.nih.gov/pubmed/35327345
http://dx.doi.org/10.3390/biomedicines10030543
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