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Structural Characterization of Mannoglucan Isolated from Ophiocordyceps sobolifera and Its Antioxidant Activities

[Image: see text] A novel polysaccharide structure (PS-T80) was collected from Ophiocordyceps sobolifera biomass and characterized via a combination of chemical and spectral analyses. Employing high-performance gel permeation chromatography (HPGPC), the average molecular weight is proven to be 7.4 ×...

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Detalles Bibliográficos
Autores principales: Le, Trung Hieu, Thi Tran, Thi Van, Tran, Van Khoa, Vu Ho, Xuan Anh, Tran, Thanh Minh, Chau Nguyen, Dang Giang, Chuong Nguyen, Thi Hong, Varma, Rajender S., Trinh, Tam Kiet, Ho, Thanh-Tam, Hac Nguyen, Thi Bach, Ahamad, Tansir, Nguyen, Chinh Chien, Le, Quyet Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945084/
https://www.ncbi.nlm.nih.gov/pubmed/35350314
http://dx.doi.org/10.1021/acsomega.1c06651
Descripción
Sumario:[Image: see text] A novel polysaccharide structure (PS-T80) was collected from Ophiocordyceps sobolifera biomass and characterized via a combination of chemical and spectral analyses. Employing high-performance gel permeation chromatography (HPGPC), the average molecular weight is proven to be 7.4 × 10(4) Da. Furthermore, a sugar composition analysis of the obtained polysaccharide suggests two main sugars, β-d-glucose and α-d-mannose, at a molar ratio of 2:1, respectively, in the backbone. The structure analysis unveils that PS-T80 is a mannoglucan, possessing the repeating unit of [→3)-β-d-Glcp-(1 → 3)-α-d-Manp-(1 → 3)-β-d-Glcp-(1→](n). Such a configuration could be considered a novel polysaccharide. Impressively, in vitro antioxidant tests revealed that PS-T80 has a promising antioxidant activity. These results demonstrate that the obtained PS is a potential bioactive material for biomedical applications.