Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products

Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to manufacturing PSCs in single-use bioreactors, par...

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Detalles Bibliográficos
Autores principales: Lee, Brian, Jung, Sunghoon, Hashimura, Yas, Lee, Maximilian, Borys, Breanna S., Dang, Tiffany, Kallos, Michael S., Rodrigues, Carlos A. V., Silva, Teresa P., Cabral, Joaquim M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945133/
https://www.ncbi.nlm.nih.gov/pubmed/35324781
http://dx.doi.org/10.3390/bioengineering9030092
Descripción
Sumario:Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to manufacturing PSCs in single-use bioreactors, particularly at larger volumetric scales. This manuscript addresses these challenges and presents potential solutions to alleviate the anticipated bottlenecks for commercial-scale manufacturing of high-quality therapeutic cells derived from PSCs.

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