Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products

Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to manufacturing PSCs in single-use bioreactors, par...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Brian, Jung, Sunghoon, Hashimura, Yas, Lee, Maximilian, Borys, Breanna S., Dang, Tiffany, Kallos, Michael S., Rodrigues, Carlos A. V., Silva, Teresa P., Cabral, Joaquim M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945133/
https://www.ncbi.nlm.nih.gov/pubmed/35324781
http://dx.doi.org/10.3390/bioengineering9030092
_version_ 1784673884678651904
author Lee, Brian
Jung, Sunghoon
Hashimura, Yas
Lee, Maximilian
Borys, Breanna S.
Dang, Tiffany
Kallos, Michael S.
Rodrigues, Carlos A. V.
Silva, Teresa P.
Cabral, Joaquim M. S.
author_facet Lee, Brian
Jung, Sunghoon
Hashimura, Yas
Lee, Maximilian
Borys, Breanna S.
Dang, Tiffany
Kallos, Michael S.
Rodrigues, Carlos A. V.
Silva, Teresa P.
Cabral, Joaquim M. S.
author_sort Lee, Brian
collection PubMed
description Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to manufacturing PSCs in single-use bioreactors, particularly at larger volumetric scales. This manuscript addresses these challenges and presents potential solutions to alleviate the anticipated bottlenecks for commercial-scale manufacturing of high-quality therapeutic cells derived from PSCs.
format Online
Article
Text
id pubmed-8945133
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89451332022-03-25 Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products Lee, Brian Jung, Sunghoon Hashimura, Yas Lee, Maximilian Borys, Breanna S. Dang, Tiffany Kallos, Michael S. Rodrigues, Carlos A. V. Silva, Teresa P. Cabral, Joaquim M. S. Bioengineering (Basel) Communication Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to manufacturing PSCs in single-use bioreactors, particularly at larger volumetric scales. This manuscript addresses these challenges and presents potential solutions to alleviate the anticipated bottlenecks for commercial-scale manufacturing of high-quality therapeutic cells derived from PSCs. MDPI 2022-02-25 /pmc/articles/PMC8945133/ /pubmed/35324781 http://dx.doi.org/10.3390/bioengineering9030092 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lee, Brian
Jung, Sunghoon
Hashimura, Yas
Lee, Maximilian
Borys, Breanna S.
Dang, Tiffany
Kallos, Michael S.
Rodrigues, Carlos A. V.
Silva, Teresa P.
Cabral, Joaquim M. S.
Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_full Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_fullStr Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_full_unstemmed Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_short Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_sort cell culture process scale-up challenges for commercial-scale manufacturing of allogeneic pluripotent stem cell products
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945133/
https://www.ncbi.nlm.nih.gov/pubmed/35324781
http://dx.doi.org/10.3390/bioengineering9030092
work_keys_str_mv AT leebrian cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT jungsunghoon cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT hashimurayas cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT leemaximilian cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT borysbreannas cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT dangtiffany cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT kallosmichaels cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT rodriguescarlosav cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT silvateresap cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts
AT cabraljoaquimms cellcultureprocessscaleupchallengesforcommercialscalemanufacturingofallogeneicpluripotentstemcellproducts

Ejemplares similares