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Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review
Coronavirus disease 2019 is characterized by its severe respiratory effects. Data early on indicated an increased risk of mortality in patients with cardiovascular comorbidities. Early reports highlighted the multisystem inflammatory syndrome, cytokine storm, and thromboembolic events as part of the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945192/ https://www.ncbi.nlm.nih.gov/pubmed/35327504 http://dx.doi.org/10.3390/biomedicines10030702 |
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author | Nappi, Francesco Giacinto, Omar Ellouze, Omar Nenna, Antonio Avtaar Singh, Sanjeet Singh Chello, Massimo Bouzguenda, Assine Copie, Xavier |
author_facet | Nappi, Francesco Giacinto, Omar Ellouze, Omar Nenna, Antonio Avtaar Singh, Sanjeet Singh Chello, Massimo Bouzguenda, Assine Copie, Xavier |
author_sort | Nappi, Francesco |
collection | PubMed |
description | Coronavirus disease 2019 is characterized by its severe respiratory effects. Data early on indicated an increased risk of mortality in patients with cardiovascular comorbidities. Early reports highlighted the multisystem inflammatory syndrome, cytokine storm, and thromboembolic events as part of the disease processes. The aim of this review is to assess the association between COVID-19 and its thrombotic complications, specifically related to the cardiovascular system. The role of neutrophil extracellular traps (NETs) is explored in the pathogenesis of the disease. The structure and anatomy of the virus are pivotal to its virulence in comparison to other α and β Coronaviridae (HCoV-229E, HCoV-OC43, HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1). In particular, the host interaction and response may explain the variability of severity in patients. Angio tensin-converting enzyme 2 (ACE2) activation may be implicated in the cardiovascular and throm bogenic potential of the disease. The virus may also have direct effects on the endothelial lining affecting hemostasis and resulting in thrombosis through several mechanisms. Dipyridamole may have a therapeutic benefit in NET suppression. Therapeutic avenues should be concentrated on the different pathophysiological steps involving the virus and the host. |
format | Online Article Text |
id | pubmed-8945192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89451922022-03-25 Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review Nappi, Francesco Giacinto, Omar Ellouze, Omar Nenna, Antonio Avtaar Singh, Sanjeet Singh Chello, Massimo Bouzguenda, Assine Copie, Xavier Biomedicines Review Coronavirus disease 2019 is characterized by its severe respiratory effects. Data early on indicated an increased risk of mortality in patients with cardiovascular comorbidities. Early reports highlighted the multisystem inflammatory syndrome, cytokine storm, and thromboembolic events as part of the disease processes. The aim of this review is to assess the association between COVID-19 and its thrombotic complications, specifically related to the cardiovascular system. The role of neutrophil extracellular traps (NETs) is explored in the pathogenesis of the disease. The structure and anatomy of the virus are pivotal to its virulence in comparison to other α and β Coronaviridae (HCoV-229E, HCoV-OC43, HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1). In particular, the host interaction and response may explain the variability of severity in patients. Angio tensin-converting enzyme 2 (ACE2) activation may be implicated in the cardiovascular and throm bogenic potential of the disease. The virus may also have direct effects on the endothelial lining affecting hemostasis and resulting in thrombosis through several mechanisms. Dipyridamole may have a therapeutic benefit in NET suppression. Therapeutic avenues should be concentrated on the different pathophysiological steps involving the virus and the host. MDPI 2022-03-18 /pmc/articles/PMC8945192/ /pubmed/35327504 http://dx.doi.org/10.3390/biomedicines10030702 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nappi, Francesco Giacinto, Omar Ellouze, Omar Nenna, Antonio Avtaar Singh, Sanjeet Singh Chello, Massimo Bouzguenda, Assine Copie, Xavier Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review |
title | Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review |
title_full | Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review |
title_fullStr | Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review |
title_full_unstemmed | Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review |
title_short | Association between COVID-19 Diagnosis and Coronary Artery Thrombosis: A Narrative Review |
title_sort | association between covid-19 diagnosis and coronary artery thrombosis: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945192/ https://www.ncbi.nlm.nih.gov/pubmed/35327504 http://dx.doi.org/10.3390/biomedicines10030702 |
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