Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic p75(NTR) receptors. NGF has been shown to slow o...

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Detalles Bibliográficos
Autores principales: Rogdakis, Thanasis, Charou, Despoina, Latorrata, Alessia, Papadimitriou, Eleni, Tsengenes, Alexandros, Athanasiou, Christina, Papadopoulou, Marianna, Chalikiopoulou, Constantina, Katsila, Theodora, Ramos, Isbaal, Prousis, Kyriakos C., Wade, Rebecca C., Sidiropoulou, Kyriaki, Calogeropoulou, Theodora, Gravanis, Achille, Charalampopoulos, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945229/
https://www.ncbi.nlm.nih.gov/pubmed/35327415
http://dx.doi.org/10.3390/biomedicines10030614

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