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The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia
Theory of mind (ToM, the ability to attribute mental states to others) deficit is a frequent finding in neurodegenerative conditions, mediated by a diffuse brain network confirmed by (18)F-FDG-PET and MR imaging, involving frontal, temporal and parietal areas. However, the role of hubs and spokes ne...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945345/ https://www.ncbi.nlm.nih.gov/pubmed/35327346 http://dx.doi.org/10.3390/biomedicines10030544 |
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author | Orso, Beatrice Lorenzini, Luigi Arnaldi, Dario Girtler, Nicola Brugnolo, Andrea Doglione, Elisa Mattioli, Pietro Biassoni, Erica Massa, Federico Peira, Enrico Bauckneht, Matteo Donegani, Maria I. Morbelli, Silvia Nobili, Flavio Pardini, Matteo |
author_facet | Orso, Beatrice Lorenzini, Luigi Arnaldi, Dario Girtler, Nicola Brugnolo, Andrea Doglione, Elisa Mattioli, Pietro Biassoni, Erica Massa, Federico Peira, Enrico Bauckneht, Matteo Donegani, Maria I. Morbelli, Silvia Nobili, Flavio Pardini, Matteo |
author_sort | Orso, Beatrice |
collection | PubMed |
description | Theory of mind (ToM, the ability to attribute mental states to others) deficit is a frequent finding in neurodegenerative conditions, mediated by a diffuse brain network confirmed by (18)F-FDG-PET and MR imaging, involving frontal, temporal and parietal areas. However, the role of hubs and spokes network regions in ToM performance, and their respective damage, is still unclear. To study this mechanism, we combined ToM testing with brain (18)F-FDG-PET imaging in 25 subjects with mild cognitive impairment due to Alzheimer’s disease (MCI–AD), 24 subjects with the behavioral variant of frontotemporal dementia (bvFTD) and 40 controls. Regions included in the ToM network were divided into hubs and spokes based on their structural connectivity and distribution of hypometabolism. The hubs of the ToM network were identified in frontal regions in both bvFTD and MCI–AD patients. A mediation analysis revealed that the impact of spokes damage on ToM performance was mediated by the integrity of hubs (p < 0.001), while the impact of hubs damage on ToM performance was independent from the integrity of spokes (p < 0.001). Our findings support the theory that a key role is played by the hubs in ToM deficits, suggesting that hubs could represent a final common pathway leading from the damage of spoke regions to clinical deficits. |
format | Online Article Text |
id | pubmed-8945345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89453452022-03-25 The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia Orso, Beatrice Lorenzini, Luigi Arnaldi, Dario Girtler, Nicola Brugnolo, Andrea Doglione, Elisa Mattioli, Pietro Biassoni, Erica Massa, Federico Peira, Enrico Bauckneht, Matteo Donegani, Maria I. Morbelli, Silvia Nobili, Flavio Pardini, Matteo Biomedicines Article Theory of mind (ToM, the ability to attribute mental states to others) deficit is a frequent finding in neurodegenerative conditions, mediated by a diffuse brain network confirmed by (18)F-FDG-PET and MR imaging, involving frontal, temporal and parietal areas. However, the role of hubs and spokes network regions in ToM performance, and their respective damage, is still unclear. To study this mechanism, we combined ToM testing with brain (18)F-FDG-PET imaging in 25 subjects with mild cognitive impairment due to Alzheimer’s disease (MCI–AD), 24 subjects with the behavioral variant of frontotemporal dementia (bvFTD) and 40 controls. Regions included in the ToM network were divided into hubs and spokes based on their structural connectivity and distribution of hypometabolism. The hubs of the ToM network were identified in frontal regions in both bvFTD and MCI–AD patients. A mediation analysis revealed that the impact of spokes damage on ToM performance was mediated by the integrity of hubs (p < 0.001), while the impact of hubs damage on ToM performance was independent from the integrity of spokes (p < 0.001). Our findings support the theory that a key role is played by the hubs in ToM deficits, suggesting that hubs could represent a final common pathway leading from the damage of spoke regions to clinical deficits. MDPI 2022-02-24 /pmc/articles/PMC8945345/ /pubmed/35327346 http://dx.doi.org/10.3390/biomedicines10030544 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Orso, Beatrice Lorenzini, Luigi Arnaldi, Dario Girtler, Nicola Brugnolo, Andrea Doglione, Elisa Mattioli, Pietro Biassoni, Erica Massa, Federico Peira, Enrico Bauckneht, Matteo Donegani, Maria I. Morbelli, Silvia Nobili, Flavio Pardini, Matteo The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia |
title | The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia |
title_full | The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia |
title_fullStr | The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia |
title_full_unstemmed | The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia |
title_short | The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer’s Disease and Frontotemporal Dementia |
title_sort | role of hub and spoke regions in theory of mind in early alzheimer’s disease and frontotemporal dementia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945345/ https://www.ncbi.nlm.nih.gov/pubmed/35327346 http://dx.doi.org/10.3390/biomedicines10030544 |
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