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Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy

Innate immunity is critical for immediate recognition and elimination of invading pathogens or defense against cancer cell growth. Dysregulation of innate immune systems is associated with the pathogenesis of different types of inflammatory diseases, including cancer. In addition, the maintenance of...

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Autores principales: Zhao, Shengyuan, Habib, Samy L., Senejani, Alireza G., Sebastian, Manu, Kidane, Dawit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945362/
https://www.ncbi.nlm.nih.gov/pubmed/35327359
http://dx.doi.org/10.3390/biomedicines10030557
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author Zhao, Shengyuan
Habib, Samy L.
Senejani, Alireza G.
Sebastian, Manu
Kidane, Dawit
author_facet Zhao, Shengyuan
Habib, Samy L.
Senejani, Alireza G.
Sebastian, Manu
Kidane, Dawit
author_sort Zhao, Shengyuan
collection PubMed
description Innate immunity is critical for immediate recognition and elimination of invading pathogens or defense against cancer cell growth. Dysregulation of innate immune systems is associated with the pathogenesis of different types of inflammatory diseases, including cancer. In addition, the maintenance of innate immune cells’ genomic integrity is crucial for the survival of all organisms. Oxidative stress generated from innate immune cells may cause self-inflicted DNA base lesions as well as DNA damage on others neighboring cells, including cancer cells. Oxidative DNA base damage is predominantly repaired by base excision repair (BER). BER process different types of DNA base lesions that are presented in cancer and innate immune cells to maintain genomic integrity. However, mutations in BER genes lead to impaired DNA repair function and cause insufficient genomic integrity. Moreover, several studies have implicated that accumulation of DNA damage leads to chromosomal instability that likely activates the innate immune signaling. Furthermore, dysregulation of BER factors in cancer cells modulate the infiltration of innate immune cells to the tumor microenvironment. In the current review, the role of BER in cancer and innate immune cells and its impact on innate immune signaling within the tumor microenvironment is summarized. This is a special issue that focuses on DNA damage and cancer therapy to demonstrate how BER inhibitor or aberrant repair modulates innate inflammatory response and impact immunotherapy approaches. Overall, the review provides substantial evidence to understand the impact of BER in innate immune response dynamics within the current immune-based therapeutic strategy.
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spelling pubmed-89453622022-03-25 Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy Zhao, Shengyuan Habib, Samy L. Senejani, Alireza G. Sebastian, Manu Kidane, Dawit Biomedicines Review Innate immunity is critical for immediate recognition and elimination of invading pathogens or defense against cancer cell growth. Dysregulation of innate immune systems is associated with the pathogenesis of different types of inflammatory diseases, including cancer. In addition, the maintenance of innate immune cells’ genomic integrity is crucial for the survival of all organisms. Oxidative stress generated from innate immune cells may cause self-inflicted DNA base lesions as well as DNA damage on others neighboring cells, including cancer cells. Oxidative DNA base damage is predominantly repaired by base excision repair (BER). BER process different types of DNA base lesions that are presented in cancer and innate immune cells to maintain genomic integrity. However, mutations in BER genes lead to impaired DNA repair function and cause insufficient genomic integrity. Moreover, several studies have implicated that accumulation of DNA damage leads to chromosomal instability that likely activates the innate immune signaling. Furthermore, dysregulation of BER factors in cancer cells modulate the infiltration of innate immune cells to the tumor microenvironment. In the current review, the role of BER in cancer and innate immune cells and its impact on innate immune signaling within the tumor microenvironment is summarized. This is a special issue that focuses on DNA damage and cancer therapy to demonstrate how BER inhibitor or aberrant repair modulates innate inflammatory response and impact immunotherapy approaches. Overall, the review provides substantial evidence to understand the impact of BER in innate immune response dynamics within the current immune-based therapeutic strategy. MDPI 2022-02-26 /pmc/articles/PMC8945362/ /pubmed/35327359 http://dx.doi.org/10.3390/biomedicines10030557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Shengyuan
Habib, Samy L.
Senejani, Alireza G.
Sebastian, Manu
Kidane, Dawit
Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
title Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
title_full Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
title_fullStr Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
title_full_unstemmed Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
title_short Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
title_sort role of base excision repair in innate immune cells and its relevance for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945362/
https://www.ncbi.nlm.nih.gov/pubmed/35327359
http://dx.doi.org/10.3390/biomedicines10030557
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