Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics

Caenorhabditis elegans is an important model used for many aspects of biological research. Its genome contains 76 genes coding for cytochromes P450 (P450s), and few data about the biochemical properties of those P450s have been published so far. However, an increasing number of articles have appeare...

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Autores principales: Larigot, Lucie, Mansuy, Daniel, Borowski, Ilona, Coumoul, Xavier, Dairou, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945457/
https://www.ncbi.nlm.nih.gov/pubmed/35327534
http://dx.doi.org/10.3390/biom12030342
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author Larigot, Lucie
Mansuy, Daniel
Borowski, Ilona
Coumoul, Xavier
Dairou, Julien
author_facet Larigot, Lucie
Mansuy, Daniel
Borowski, Ilona
Coumoul, Xavier
Dairou, Julien
author_sort Larigot, Lucie
collection PubMed
description Caenorhabditis elegans is an important model used for many aspects of biological research. Its genome contains 76 genes coding for cytochromes P450 (P450s), and few data about the biochemical properties of those P450s have been published so far. However, an increasing number of articles have appeared on their involvement in the metabolism of xenobiotics and endobiotics such as fatty acid derivatives and steroids. Moreover, the implication of some P450s in various biological functions of C. elegans, such as survival, dauer formation, life span, fat content, or lipid metabolism, without mention of the precise reaction catalyzed by those P450s, has been reported in several articles. This review presents the state of our knowledge about C. elegans P450s.
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spelling pubmed-89454572022-03-25 Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics Larigot, Lucie Mansuy, Daniel Borowski, Ilona Coumoul, Xavier Dairou, Julien Biomolecules Review Caenorhabditis elegans is an important model used for many aspects of biological research. Its genome contains 76 genes coding for cytochromes P450 (P450s), and few data about the biochemical properties of those P450s have been published so far. However, an increasing number of articles have appeared on their involvement in the metabolism of xenobiotics and endobiotics such as fatty acid derivatives and steroids. Moreover, the implication of some P450s in various biological functions of C. elegans, such as survival, dauer formation, life span, fat content, or lipid metabolism, without mention of the precise reaction catalyzed by those P450s, has been reported in several articles. This review presents the state of our knowledge about C. elegans P450s. MDPI 2022-02-22 /pmc/articles/PMC8945457/ /pubmed/35327534 http://dx.doi.org/10.3390/biom12030342 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Larigot, Lucie
Mansuy, Daniel
Borowski, Ilona
Coumoul, Xavier
Dairou, Julien
Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics
title Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics
title_full Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics
title_fullStr Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics
title_full_unstemmed Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics
title_short Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics
title_sort cytochromes p450 of caenorhabditis elegans: implication in biological functions and metabolism of xenobiotics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945457/
https://www.ncbi.nlm.nih.gov/pubmed/35327534
http://dx.doi.org/10.3390/biom12030342
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