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Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers

This study aimed at evaluating the physicochemical and biological properties of experimental epoxy-resin sealers containing polyphenols such as resveratrol and pyrogallol. A conventional epoxy resin (OB) was modified by adding different concentrations of resveratrol (RS) or pyrogallol (PY) to its co...

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Autores principales: Kharouf, Naji, Sauro, Salvatore, Hardan, Louis, Fawzi, Amr, Suhanda, Ilona Eveline, Zghal, Jihed, Addiego, Frédéric, Affolter-Zbaraszczuk, Christine, Arntz, Youri, Ball, Vincent, Meyer, Florent, Haikel, Youssef, Mancino, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945518/
https://www.ncbi.nlm.nih.gov/pubmed/35324774
http://dx.doi.org/10.3390/bioengineering9030085
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author Kharouf, Naji
Sauro, Salvatore
Hardan, Louis
Fawzi, Amr
Suhanda, Ilona Eveline
Zghal, Jihed
Addiego, Frédéric
Affolter-Zbaraszczuk, Christine
Arntz, Youri
Ball, Vincent
Meyer, Florent
Haikel, Youssef
Mancino, Davide
author_facet Kharouf, Naji
Sauro, Salvatore
Hardan, Louis
Fawzi, Amr
Suhanda, Ilona Eveline
Zghal, Jihed
Addiego, Frédéric
Affolter-Zbaraszczuk, Christine
Arntz, Youri
Ball, Vincent
Meyer, Florent
Haikel, Youssef
Mancino, Davide
author_sort Kharouf, Naji
collection PubMed
description This study aimed at evaluating the physicochemical and biological properties of experimental epoxy-resin sealers containing polyphenols such as resveratrol and pyrogallol. A conventional epoxy resin (OB) was modified by adding different concentrations of resveratrol (RS) or pyrogallol (PY) to its composition. Antibacterial and antioxidant activities, mechanical properties, along with wettability and morphological changes were investigated. The results were statistically analyzed using ANOVA and multiple comparison tests (α = 0.05). The incorporation of the tested polyphenols into the epoxy resin enhanced its mechanical properties. PY demonstrated much better antioxidant and antibacterial activities than RS, which were associated with a higher release of PY. In contrast, PY showed a higher cytotoxicity than OB and OB doped with RS. OB containing PY presented a rougher surface and higher water absorption than OB doped with RS. Both tested polyphenols caused no notable changes to the overall porosity of OB. Resveratrol and pyrogallol may not only influence the morphology and mechanical properties of epoxy-resin sealers, but could also enhance antioxidant activity and antibacterial effects against Enterococcus faecalis. Most epoxy-resin sealers currently available in the market can be considered as “passive” materials. Thus, doping their composition with specific polyphenols may be a suitable strategy to confer some antibacterial properties, antioxidant potential, along with improvement of some mechanical properties.
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spelling pubmed-89455182022-03-25 Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers Kharouf, Naji Sauro, Salvatore Hardan, Louis Fawzi, Amr Suhanda, Ilona Eveline Zghal, Jihed Addiego, Frédéric Affolter-Zbaraszczuk, Christine Arntz, Youri Ball, Vincent Meyer, Florent Haikel, Youssef Mancino, Davide Bioengineering (Basel) Article This study aimed at evaluating the physicochemical and biological properties of experimental epoxy-resin sealers containing polyphenols such as resveratrol and pyrogallol. A conventional epoxy resin (OB) was modified by adding different concentrations of resveratrol (RS) or pyrogallol (PY) to its composition. Antibacterial and antioxidant activities, mechanical properties, along with wettability and morphological changes were investigated. The results were statistically analyzed using ANOVA and multiple comparison tests (α = 0.05). The incorporation of the tested polyphenols into the epoxy resin enhanced its mechanical properties. PY demonstrated much better antioxidant and antibacterial activities than RS, which were associated with a higher release of PY. In contrast, PY showed a higher cytotoxicity than OB and OB doped with RS. OB containing PY presented a rougher surface and higher water absorption than OB doped with RS. Both tested polyphenols caused no notable changes to the overall porosity of OB. Resveratrol and pyrogallol may not only influence the morphology and mechanical properties of epoxy-resin sealers, but could also enhance antioxidant activity and antibacterial effects against Enterococcus faecalis. Most epoxy-resin sealers currently available in the market can be considered as “passive” materials. Thus, doping their composition with specific polyphenols may be a suitable strategy to confer some antibacterial properties, antioxidant potential, along with improvement of some mechanical properties. MDPI 2022-02-22 /pmc/articles/PMC8945518/ /pubmed/35324774 http://dx.doi.org/10.3390/bioengineering9030085 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kharouf, Naji
Sauro, Salvatore
Hardan, Louis
Fawzi, Amr
Suhanda, Ilona Eveline
Zghal, Jihed
Addiego, Frédéric
Affolter-Zbaraszczuk, Christine
Arntz, Youri
Ball, Vincent
Meyer, Florent
Haikel, Youssef
Mancino, Davide
Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers
title Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers
title_full Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers
title_fullStr Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers
title_full_unstemmed Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers
title_short Impacts of Resveratrol and Pyrogallol on Physicochemical, Mechanical and Biological Properties of Epoxy-Resin Sealers
title_sort impacts of resveratrol and pyrogallol on physicochemical, mechanical and biological properties of epoxy-resin sealers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945518/
https://www.ncbi.nlm.nih.gov/pubmed/35324774
http://dx.doi.org/10.3390/bioengineering9030085
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