Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition

Acute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation (OxPhos) for survival, and they continually adapt to fluctuations in nutrient and oxygen availability in the bone marrow (BM) microenvironment. We investigated how the BM microenvironment affects the response to OxP...

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Detalles Bibliográficos
Autores principales: Saito, Kaori, Zhang, Qi, Yang, Haeun, Yamatani, Kotoko, Ai, Tomohiko, Ruvolo, Vivian, Baran, Natalia, Cai, Tianyu, Ma, Helen, Jacamo, Rodrigo, Kuruvilla, Vinitha, Imoto, Junichi, Kinjo, Sonoko, Ikeo, Kazuho, Moriya, Kaori, Suzuki, Koya, Miida, Takashi, Kim, Yong-Mi, Vellano, Christopher P., Andreeff, Michael, Marszalek, Joseph R., Tabe, Yoko, Konopleva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945617/
https://www.ncbi.nlm.nih.gov/pubmed/34507353
http://dx.doi.org/10.1182/bloodadvances.2020003661

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