Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging

During aging, hematopoietic stem cell (HSC) function wanes with important biological and clinical implications for benign and malignant hematology, and other comorbidities, such as cardiovascular disease. However, the molecular mechanisms regulating HSC aging remain incompletely defined. GATA2 haplo...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelfattah, Ali, Hughes-Davies, Antonia, Clayfield, Liam, Menendez-Gonzalez, Juan Bautista, Almotiri, Alhomidi, Alotaibi, Badi, Tonks, Alex, Rodrigues, Neil P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945642/
https://www.ncbi.nlm.nih.gov/pubmed/34496012
http://dx.doi.org/10.1182/bloodadvances.2021004726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945642/
https://www.ncbi.nlm.nih.gov/pubmed/34496012
http://dx.doi.org/10.1182/bloodadvances.2021004726

Ejemplares similares