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Biodegradable Magnesium Biomaterials—Road to the Clinic

In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents,...

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Detalles Bibliográficos
Autores principales: Amukarimi, Shukufe, Mozafari, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945684/
https://www.ncbi.nlm.nih.gov/pubmed/35324796
http://dx.doi.org/10.3390/bioengineering9030107
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author Amukarimi, Shukufe
Mozafari, Masoud
author_facet Amukarimi, Shukufe
Mozafari, Masoud
author_sort Amukarimi, Shukufe
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description In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented.
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spelling pubmed-89456842022-03-25 Biodegradable Magnesium Biomaterials—Road to the Clinic Amukarimi, Shukufe Mozafari, Masoud Bioengineering (Basel) Review In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With the use of biodegradable Mg biomaterials, patients would not suffer second surgery and surgical pain anymore. Be that as it may, the main drawbacks of these biomaterials are the high corrosion rate and unexpected degradation in physiological environments. Since biodegradable Mg-based implants are expected to show controllable degradation and match the requirements of specific applications, various techniques, such as designing a magnesium alloy and modifying the surface characteristics, are employed to tailor the degradation rate. In this paper, some fundamentals and particular aspects of magnesium degradation in physiological environments are summarized, and approaches to control the degradation behavior of Mg-based biomaterials are presented. MDPI 2022-03-05 /pmc/articles/PMC8945684/ /pubmed/35324796 http://dx.doi.org/10.3390/bioengineering9030107 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Amukarimi, Shukufe
Mozafari, Masoud
Biodegradable Magnesium Biomaterials—Road to the Clinic
title Biodegradable Magnesium Biomaterials—Road to the Clinic
title_full Biodegradable Magnesium Biomaterials—Road to the Clinic
title_fullStr Biodegradable Magnesium Biomaterials—Road to the Clinic
title_full_unstemmed Biodegradable Magnesium Biomaterials—Road to the Clinic
title_short Biodegradable Magnesium Biomaterials—Road to the Clinic
title_sort biodegradable magnesium biomaterials—road to the clinic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945684/
https://www.ncbi.nlm.nih.gov/pubmed/35324796
http://dx.doi.org/10.3390/bioengineering9030107
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