Cargando…
Present Application and Perspectives of Organoid Imaging Technology
An organoid is a miniaturized and simplified in vitro model with a similar structure and function to a real organ. In recent years, the use of organoids has increased explosively in the field of growth and development, disease simulation, drug screening, cell therapy, etc. In order to obtain necessa...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945799/ https://www.ncbi.nlm.nih.gov/pubmed/35324810 http://dx.doi.org/10.3390/bioengineering9030121 |
_version_ | 1784674040004214784 |
---|---|
author | Fei, Keyi Zhang, Jinze Yuan, Jin Xiao, Peng |
author_facet | Fei, Keyi Zhang, Jinze Yuan, Jin Xiao, Peng |
author_sort | Fei, Keyi |
collection | PubMed |
description | An organoid is a miniaturized and simplified in vitro model with a similar structure and function to a real organ. In recent years, the use of organoids has increased explosively in the field of growth and development, disease simulation, drug screening, cell therapy, etc. In order to obtain necessary information, such as morphological structure, cell function and dynamic signals, it is necessary and important to directly monitor the culture process of organoids. Among different detection technologies, imaging technology is a simple and convenient choice and can realize direct observation and quantitative research. In this review, the principle, advantages and disadvantages of imaging technologies that have been applied in organoids research are introduced. We also offer an overview of prospective technologies for organoid imaging. This review aims to help biologists find appropriate imaging techniques for different areas of organoid research, and also contribute to the development of organoid imaging systems. |
format | Online Article Text |
id | pubmed-8945799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89457992022-03-25 Present Application and Perspectives of Organoid Imaging Technology Fei, Keyi Zhang, Jinze Yuan, Jin Xiao, Peng Bioengineering (Basel) Review An organoid is a miniaturized and simplified in vitro model with a similar structure and function to a real organ. In recent years, the use of organoids has increased explosively in the field of growth and development, disease simulation, drug screening, cell therapy, etc. In order to obtain necessary information, such as morphological structure, cell function and dynamic signals, it is necessary and important to directly monitor the culture process of organoids. Among different detection technologies, imaging technology is a simple and convenient choice and can realize direct observation and quantitative research. In this review, the principle, advantages and disadvantages of imaging technologies that have been applied in organoids research are introduced. We also offer an overview of prospective technologies for organoid imaging. This review aims to help biologists find appropriate imaging techniques for different areas of organoid research, and also contribute to the development of organoid imaging systems. MDPI 2022-03-16 /pmc/articles/PMC8945799/ /pubmed/35324810 http://dx.doi.org/10.3390/bioengineering9030121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fei, Keyi Zhang, Jinze Yuan, Jin Xiao, Peng Present Application and Perspectives of Organoid Imaging Technology |
title | Present Application and Perspectives of Organoid Imaging Technology |
title_full | Present Application and Perspectives of Organoid Imaging Technology |
title_fullStr | Present Application and Perspectives of Organoid Imaging Technology |
title_full_unstemmed | Present Application and Perspectives of Organoid Imaging Technology |
title_short | Present Application and Perspectives of Organoid Imaging Technology |
title_sort | present application and perspectives of organoid imaging technology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945799/ https://www.ncbi.nlm.nih.gov/pubmed/35324810 http://dx.doi.org/10.3390/bioengineering9030121 |
work_keys_str_mv | AT feikeyi presentapplicationandperspectivesoforganoidimagingtechnology AT zhangjinze presentapplicationandperspectivesoforganoidimagingtechnology AT yuanjin presentapplicationandperspectivesoforganoidimagingtechnology AT xiaopeng presentapplicationandperspectivesoforganoidimagingtechnology |