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Present Application and Perspectives of Organoid Imaging Technology

An organoid is a miniaturized and simplified in vitro model with a similar structure and function to a real organ. In recent years, the use of organoids has increased explosively in the field of growth and development, disease simulation, drug screening, cell therapy, etc. In order to obtain necessa...

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Detalles Bibliográficos
Autores principales: Fei, Keyi, Zhang, Jinze, Yuan, Jin, Xiao, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945799/
https://www.ncbi.nlm.nih.gov/pubmed/35324810
http://dx.doi.org/10.3390/bioengineering9030121
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author Fei, Keyi
Zhang, Jinze
Yuan, Jin
Xiao, Peng
author_facet Fei, Keyi
Zhang, Jinze
Yuan, Jin
Xiao, Peng
author_sort Fei, Keyi
collection PubMed
description An organoid is a miniaturized and simplified in vitro model with a similar structure and function to a real organ. In recent years, the use of organoids has increased explosively in the field of growth and development, disease simulation, drug screening, cell therapy, etc. In order to obtain necessary information, such as morphological structure, cell function and dynamic signals, it is necessary and important to directly monitor the culture process of organoids. Among different detection technologies, imaging technology is a simple and convenient choice and can realize direct observation and quantitative research. In this review, the principle, advantages and disadvantages of imaging technologies that have been applied in organoids research are introduced. We also offer an overview of prospective technologies for organoid imaging. This review aims to help biologists find appropriate imaging techniques for different areas of organoid research, and also contribute to the development of organoid imaging systems.
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spelling pubmed-89457992022-03-25 Present Application and Perspectives of Organoid Imaging Technology Fei, Keyi Zhang, Jinze Yuan, Jin Xiao, Peng Bioengineering (Basel) Review An organoid is a miniaturized and simplified in vitro model with a similar structure and function to a real organ. In recent years, the use of organoids has increased explosively in the field of growth and development, disease simulation, drug screening, cell therapy, etc. In order to obtain necessary information, such as morphological structure, cell function and dynamic signals, it is necessary and important to directly monitor the culture process of organoids. Among different detection technologies, imaging technology is a simple and convenient choice and can realize direct observation and quantitative research. In this review, the principle, advantages and disadvantages of imaging technologies that have been applied in organoids research are introduced. We also offer an overview of prospective technologies for organoid imaging. This review aims to help biologists find appropriate imaging techniques for different areas of organoid research, and also contribute to the development of organoid imaging systems. MDPI 2022-03-16 /pmc/articles/PMC8945799/ /pubmed/35324810 http://dx.doi.org/10.3390/bioengineering9030121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fei, Keyi
Zhang, Jinze
Yuan, Jin
Xiao, Peng
Present Application and Perspectives of Organoid Imaging Technology
title Present Application and Perspectives of Organoid Imaging Technology
title_full Present Application and Perspectives of Organoid Imaging Technology
title_fullStr Present Application and Perspectives of Organoid Imaging Technology
title_full_unstemmed Present Application and Perspectives of Organoid Imaging Technology
title_short Present Application and Perspectives of Organoid Imaging Technology
title_sort present application and perspectives of organoid imaging technology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945799/
https://www.ncbi.nlm.nih.gov/pubmed/35324810
http://dx.doi.org/10.3390/bioengineering9030121
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