Cargando…

Together Intra-Tumor Hypoxia and Macrophagic Immunity Are Driven Worst Outcome in Pediatric High-Grade Osteosarcomas

SIMPLE SUMMARY: Radiological and immunohistochemical data were correlated with the outcome in a retrospective monocentric cohort of 30 pediatric osteosarcomas (OTS). A necrotic volume of more than 50 cm(3) at diagnosis was significantly linked to a worse overall survival (OS). Regarding immunohistoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nazon, Charlotte, Pierrevelcin, Marina, Willaume, Thibault, Lhermitte, Benoît, Weingertner, Noelle, Marco, Antonio Di, Bund, Laurent, Vincent, Florence, Bierry, Guillaume, Gomez-Brouchet, Anne, Redini, Françoise, Gaspar, Nathalie, Dontenwill, Monique, Entz-Werle, Natacha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945994/ https://www.ncbi.nlm.nih.gov/pubmed/35326631 http://dx.doi.org/10.3390/cancers14061482

Ejemplares similares

Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability
por: Pierrevelcin, Marina, et al.
Publicado: (2020)

HGG-39. Integrative analyses of BRAFp.v600e mutated gliomas: from epigenetic to metabolic characteristics
por: Lhermitte, Benoit, et al.
Publicado: (2022)

HGG-36. HIF-2: A NEW DRUG TARGET IN PEDIATRIC HIGH-GRADE GLIOMA WITH PROMISING PRECLINICAL RESULTS
por: Fuchs, Quentin, et al.
Publicado: (2020)

Hypoxia Inducible Factors’ Signaling in Pediatric High-Grade Gliomas: Role, Modelization and Innovative Targeted Approaches
por: Fuchs, Quentin, et al.
Publicado: (2020)

TBIO-17. INTEGRATIVE ANALYSES OF BRAFv600e MUTATED GLIOMAS: FROM MOLECULAR BIOLOGY TO RADIOLOGY AND TREATMENTS
por: Lhermitte, Benoit, et al.
Publicado: (2020)

HGG-34. A DNA DAMAGE REPAIR SIGNATURE IN PRIMARY AND RECURRENT PEDIATRIC HIGH-GRADE GLIOMAS: PROGNOSTIC AND THERAPEUTIC VALUE
por: Entz-Werle, Natacha, et al.
Publicado: (2021)

Glioblastoma Metabolism: Insights and Therapeutic Strategies
por: Bernhard, Chloé, et al.
Publicado: (2023)

Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment?
por: Gomez-Brouchet, Anne, et al.
Publicado: (2021)

Exercise-related leg muscle signal changes: assessment using diffusion-weighted MRI
por: Kolmer, Floriane, et al.
Publicado: (2023)

DIPG-31. HIF-1A AND HIF-2A COMBINATORIAL TARGETING OR HOW TO REVERSE THEIR BALANCED ONCOGENIC IMPACT
por: Fuchs, Quentin, et al.
Publicado: (2023)

A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value
por: Entz-Werlé, Natacha, et al.
Publicado: (2021)

Molecular Heterogeneity in BRAF-Mutant Gliomas: Diagnostic, Prognostic, and Therapeutic Implications
por: Lhermitte, Benoit, et al.
Publicado: (2023)

Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition
por: Nguyen, Aurélia, et al.
Publicado: (2017)

Jaw osteosarcoma models in mice: first description
por: Bertin, Hélios, et al.
Publicado: (2019)

Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity
por: Blandin, Anne-Florence, et al.
Publicado: (2019)

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin
por: Sani, Saidu, et al.
Publicado: (2022)

Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse
por: Nguyen, Aurelia, et al.
Publicado: (2013)

DIPG-30. HIF2 OVEREXPRESSION DICTATES AGGRESSIVENESS ADDITIONALLY TO TP53 MUTATIONS IN H3.3K27M PEDIATRIC HIGH-GRADE GLIOMAS THROUGH RAS-MAPK AND WNT/BCATENIN PATHWAYS
por: Fuchs, Quentin, et al.
Publicado: (2023)

Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment
por: Verrecchia, Franck, et al.
Publicado: (2018)

LIM Kinases in Osteosarcoma Development
por: Brion, Régis, et al.
Publicado: (2021)

Characterization of the Tumor Microenvironment in Jaw Osteosarcomas, towards Prognostic Markers and New Therapeutic Targets
por: Bertin, Hélios, et al.
Publicado: (2023)

Current Therapeutic Strategies and Novel Approaches in Osteosarcoma
por: Ando, Kosei, et al.
Publicado: (2013)

LGG-16. Retrospective and integrative analyses of molecular characteristics and their specific imaging parameters in pediatric grade 1 gliomas.
por: Courant, Marie, et al.
Publicado: (2022)

The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
por: Corre, Isabelle, et al.
Publicado: (2020)

Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas
por: Pinto, Lia, et al.
Publicado: (2021)

DIPG-33. P16 IMMUNOHISTOCHEMICAL EXPRESSION AS A SURROGATE ASSESSMENT OF CDKN2A ALTERATION IN GLIOMAS LEADING TO PROGNOSTIC SIGNIFICANCES
por: Geyer, Lucas, et al.
Publicado: (2023)

p16 Immunohistochemical Expression as a Surrogate Assessment of CDKN2A Alteration in Gliomas Leading to Prognostic Significances
por: Geyer, Lucas, et al.
Publicado: (2023)

Molecular Alterations Associated with Osteosarcoma Development
por: Ando, Kosei, et al.
Publicado: (2012)

Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells
por: Veys, Clément, et al.
Publicado: (2022)

TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression
por: Lamora, Audrey, et al.
Publicado: (2016)

The worst is not, so long as we can say “this is the worst”
por: Bate, Jonathan
Publicado: (2020)

Expecting the Worst
por: Payne, John, et al.
Publicado: (1970)

Sirolimus Pharmacokinetics Variability Points to the Relevance of Therapeutic Drug Monitoring in Pediatric Oncology
por: Sabo, Amelia-Naomi, et al.
Publicado: (2021)

Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases
por: Lamora, Audrey, et al.
Publicado: (2015)

Bone Sarcomas: From Biology to Targeted Therapies
por: Gaspar, Nathalie, et al.
Publicado: (2012)

MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells
por: Veys, Clément, et al.
Publicado: (2023)

The world's worst problems
por: Dodds, Walter
Publicado: (2019)

Worst Headaches of the Humankind
por: Chowdhury, Debashish
Publicado: (2018)

CEPI: preparing for the worst
por: Burki, Talha
Publicado: (2017)

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
por: Schaffner, Florence, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_m2e40n5vb8e8c6o4ano0ir29j4