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In Vivo Basilar Membrane Time Delays in Humans
To date, objective measurements and psychophysical experiments have been used to measure frequency dependent basilar membrane (BM) delays in humans; however, in vivo measurements have not been made. This study aimed to measure BM delays by performing intracochlear electrocochleography in cochlear im...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946056/ https://www.ncbi.nlm.nih.gov/pubmed/35326357 http://dx.doi.org/10.3390/brainsci12030400 |
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author | Polak, Marek Lorens, Artur Walkowiak, Adam Furmanek, Mariusz Skarzynski, Piotr Henryk Skarzynski, Henryk |
author_facet | Polak, Marek Lorens, Artur Walkowiak, Adam Furmanek, Mariusz Skarzynski, Piotr Henryk Skarzynski, Henryk |
author_sort | Polak, Marek |
collection | PubMed |
description | To date, objective measurements and psychophysical experiments have been used to measure frequency dependent basilar membrane (BM) delays in humans; however, in vivo measurements have not been made. This study aimed to measure BM delays by performing intracochlear electrocochleography in cochlear implant recipients. Sixteen subjects with various degrees of hearing abilities were selected. Postoperative Computer Tomography was performed to determine electrode locations. Electrical potentials in response to acoustic tone pips at 0.25, 0.5, 1, 2, and 4 kHz and clicks were recorded with electrodes at the frequency specific region. The electrode array was inserted up to the characteristic cochlear frequency region of 250 Hz for 6 subjects. Furthermore, the array was inserted in the region of 500 Hz for 15 subjects, and 1, 2, and 4 kHz were reached in all subjects. Intracochlear electrocochleography for each frequency-specific tone pip and clicks showed detectable responses in all subjects. The latencies differed among the cochlear location and the cochlear microphonic (CM) onset latency increased with decreasing frequency and were consistent with click derived band technique. Accordingly, BM delays in humans could be derived. The BM delays increased systematically along the cochlea from basal to apical end and were in accordance with Ruggero and Temchin, 2007. |
format | Online Article Text |
id | pubmed-8946056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89460562022-03-25 In Vivo Basilar Membrane Time Delays in Humans Polak, Marek Lorens, Artur Walkowiak, Adam Furmanek, Mariusz Skarzynski, Piotr Henryk Skarzynski, Henryk Brain Sci Article To date, objective measurements and psychophysical experiments have been used to measure frequency dependent basilar membrane (BM) delays in humans; however, in vivo measurements have not been made. This study aimed to measure BM delays by performing intracochlear electrocochleography in cochlear implant recipients. Sixteen subjects with various degrees of hearing abilities were selected. Postoperative Computer Tomography was performed to determine electrode locations. Electrical potentials in response to acoustic tone pips at 0.25, 0.5, 1, 2, and 4 kHz and clicks were recorded with electrodes at the frequency specific region. The electrode array was inserted up to the characteristic cochlear frequency region of 250 Hz for 6 subjects. Furthermore, the array was inserted in the region of 500 Hz for 15 subjects, and 1, 2, and 4 kHz were reached in all subjects. Intracochlear electrocochleography for each frequency-specific tone pip and clicks showed detectable responses in all subjects. The latencies differed among the cochlear location and the cochlear microphonic (CM) onset latency increased with decreasing frequency and were consistent with click derived band technique. Accordingly, BM delays in humans could be derived. The BM delays increased systematically along the cochlea from basal to apical end and were in accordance with Ruggero and Temchin, 2007. MDPI 2022-03-17 /pmc/articles/PMC8946056/ /pubmed/35326357 http://dx.doi.org/10.3390/brainsci12030400 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Polak, Marek Lorens, Artur Walkowiak, Adam Furmanek, Mariusz Skarzynski, Piotr Henryk Skarzynski, Henryk In Vivo Basilar Membrane Time Delays in Humans |
title | In Vivo Basilar Membrane Time Delays in Humans |
title_full | In Vivo Basilar Membrane Time Delays in Humans |
title_fullStr | In Vivo Basilar Membrane Time Delays in Humans |
title_full_unstemmed | In Vivo Basilar Membrane Time Delays in Humans |
title_short | In Vivo Basilar Membrane Time Delays in Humans |
title_sort | in vivo basilar membrane time delays in humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946056/ https://www.ncbi.nlm.nih.gov/pubmed/35326357 http://dx.doi.org/10.3390/brainsci12030400 |
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