Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases

Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence ha...

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Detalles Bibliográficos
Autores principales: Diaz, Stephanie, Wang, Kankan, Sjögren, Benita, Liu, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946067/
https://www.ncbi.nlm.nih.gov/pubmed/35327608
http://dx.doi.org/10.3390/biom12030416
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author Diaz, Stephanie
Wang, Kankan
Sjögren, Benita
Liu, Xing
author_facet Diaz, Stephanie
Wang, Kankan
Sjögren, Benita
Liu, Xing
author_sort Diaz, Stephanie
collection PubMed
description Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed.
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spelling pubmed-89460672022-03-25 Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases Diaz, Stephanie Wang, Kankan Sjögren, Benita Liu, Xing Biomolecules Review Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed. MDPI 2022-03-08 /pmc/articles/PMC8946067/ /pubmed/35327608 http://dx.doi.org/10.3390/biom12030416 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diaz, Stephanie
Wang, Kankan
Sjögren, Benita
Liu, Xing
Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
title Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
title_full Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
title_fullStr Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
title_full_unstemmed Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
title_short Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
title_sort roles of cullin-ring ubiquitin ligases in cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946067/
https://www.ncbi.nlm.nih.gov/pubmed/35327608
http://dx.doi.org/10.3390/biom12030416
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AT sjogrenbenita rolesofcullinringubiquitinligasesincardiovasculardiseases
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