Cargando…

The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers

The Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and tumor progression, also playing an important role in subverting immune responses...

Descripción completa

Detalles Bibliográficos
Autores principales: Biggi, Alison Felipe Bordini, Elgui de Oliveira, Deilson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946074/
https://www.ncbi.nlm.nih.gov/pubmed/35327589
http://dx.doi.org/10.3390/biom12030397
_version_ 1784674107431845888
author Biggi, Alison Felipe Bordini
Elgui de Oliveira, Deilson
author_facet Biggi, Alison Felipe Bordini
Elgui de Oliveira, Deilson
author_sort Biggi, Alison Felipe Bordini
collection PubMed
description The Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and tumor progression, also playing an important role in subverting immune responses against cancers. The homeostasis of the immune system is tightly regulated by inhibitory mechanisms affecting key immune effectors, such as T lymphocytes and NK cells. Collectively known as immune checkpoints, these mechanisms rely on a set of cellular receptors and ligands. These molecules may be candidate targets for immune checkpoints blockade—an emergent and promising modality of immunotherapy already proven to be valuable for a variety of human cancers. The EBV was lately suspected to interfere with the expression of immune checkpoint molecules, notably PD-1 and its ligands, found to be overexpressed in cases of Hodgkin lymphoma, nasopharyngeal, and gastric adenocarcinomas associated with the viral infection. Even though there is compelling evidence showing that the EBV interferes with other immune checkpoint regulators (e.g., CTLA-4, LAG-3, TIM-3, and VISTA), the published data are still scarce. Herein, we discuss the current state of the knowledge on how the EBV interferes with the activity of immune checkpoints regulators, as well as its implications considering the immune checkpoints blockade for clinical management of the EBV-associated malignancies, notably lymphomas.
format Online
Article
Text
id pubmed-8946074
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89460742022-03-25 The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers Biggi, Alison Felipe Bordini Elgui de Oliveira, Deilson Biomolecules Review The Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and tumor progression, also playing an important role in subverting immune responses against cancers. The homeostasis of the immune system is tightly regulated by inhibitory mechanisms affecting key immune effectors, such as T lymphocytes and NK cells. Collectively known as immune checkpoints, these mechanisms rely on a set of cellular receptors and ligands. These molecules may be candidate targets for immune checkpoints blockade—an emergent and promising modality of immunotherapy already proven to be valuable for a variety of human cancers. The EBV was lately suspected to interfere with the expression of immune checkpoint molecules, notably PD-1 and its ligands, found to be overexpressed in cases of Hodgkin lymphoma, nasopharyngeal, and gastric adenocarcinomas associated with the viral infection. Even though there is compelling evidence showing that the EBV interferes with other immune checkpoint regulators (e.g., CTLA-4, LAG-3, TIM-3, and VISTA), the published data are still scarce. Herein, we discuss the current state of the knowledge on how the EBV interferes with the activity of immune checkpoints regulators, as well as its implications considering the immune checkpoints blockade for clinical management of the EBV-associated malignancies, notably lymphomas. MDPI 2022-03-04 /pmc/articles/PMC8946074/ /pubmed/35327589 http://dx.doi.org/10.3390/biom12030397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Biggi, Alison Felipe Bordini
Elgui de Oliveira, Deilson
The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
title The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
title_full The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
title_fullStr The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
title_full_unstemmed The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
title_short The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
title_sort epstein-barr virus hacks immune checkpoints: evidence and consequences for lymphoproliferative disorders and cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946074/
https://www.ncbi.nlm.nih.gov/pubmed/35327589
http://dx.doi.org/10.3390/biom12030397
work_keys_str_mv AT biggialisonfelipebordini theepsteinbarrvirushacksimmunecheckpointsevidenceandconsequencesforlymphoproliferativedisordersandcancers
AT elguideoliveiradeilson theepsteinbarrvirushacksimmunecheckpointsevidenceandconsequencesforlymphoproliferativedisordersandcancers
AT biggialisonfelipebordini epsteinbarrvirushacksimmunecheckpointsevidenceandconsequencesforlymphoproliferativedisordersandcancers
AT elguideoliveiradeilson epsteinbarrvirushacksimmunecheckpointsevidenceandconsequencesforlymphoproliferativedisordersandcancers